Ectopic Adipose Tissue in Subsistence Populations with Minimal Coronary Disease, Large Left Atria, and Very Low Rates of Atrial Fibrillation

Randall C. Thompson, Benjamin C. Trumble, Daniel Cummings, Angela Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin Gans, Samantha I. King, Edmond Seabright, Caleb Ellicott Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido Lombardi, Linda Sutherland, James Sutherland, Christopher Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S Thomas, Jagat Narula, Domini Dey, Michael Gurven and Hillard Kaplan
Additional contact information
Randall C. Thompson: Institute of Kansas City, UMKC - University of Missouri [Kansas City] - University of Missouri System
Benjamin C. Trumble: ASU - Arizona State University [Tempe]
Daniel Cummings: Chapman University
Angela Neunuebel: Institute of Kansas City
Paul L. Hooper: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Samuel Wann: Department of Neuroscience, School of Medicine, University of New Mexico, 915 Caminode salud NE, Reginal Heber Fitz Hall 145, Albuquerque, NM 87131, USA.
Adel H. Allam: Al-Azhar University [Cairo, Egypt]
Frances Neunuebel: Institute of Kansas City
Benjamin Gans: Institute of Kansas City
Samantha I. King: Institute of Kansas City
Edmond Seabright: Al-Azhar University [Cairo, Egypt]
Caleb Ellicott Finch: USC - University of Southern California
Margaret Gatz: USC - University of Southern California
Kenneth Buetow: USC - University of Southern California
Michael I. Miyamoto: Mission Heritage Medical Group, Providence Health, Mission Viejo,
Guido Lombardi: UPCH - Universidad Peruana Cayetano Heredia
Linda Sutherland: MemorialCare Health Systems, Fountain Valley, California
James Sutherland: MemorialCare Health Systems, Fountain Valley, California
Christopher Ward: Institute of Kansas City
Madeleine J. Lee: Institute of Kansas City
Ashna Mahadev: Institute of Kansas City
Daniel Eid Rodriguez: Mizzou - University of Missouri [Columbia] - University of Missouri System
David E. Michalik: UC - University of California
Chris Rowan: University of Nevada [Reno]
Tianyu Cao: UC - University of California
Jonathan Stieglitz: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Cameron M. Quick: University of Missouri [St. Louis] - University of Missouri System
Gregory S Thomas: MemorialCare Health Systems, Fountain Valley, California
Jagat Narula: Institute of Kansas City
Domini Dey: Institute of Kansas City
Michael Gurven: UC - University of California
Hillard Kaplan: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement

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Abstract: Background Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations. Methods We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.3±10.5 y, 51.6% male), 440 Moseten (55.9±10.4 y, 53.6% male) to 955 U.S. (56.8±10.8 y, 51.6% male) subjects. Results Tsimane and Moseten had 43%-52% lower EFT, EFV, TFV, and 48-92% less CAC and TAC, respectively than the U.S. cohort. Mean liver measurements were 14-22% denser and LA diameters 10-14% larger (≈ 40% larger by volume). For EFV, Tsimane, Moseten, and U.S. cohorts averaged 54.2±25.6, 60.3±35.1, and 106±53.5 cc, respectively (p

Keywords: Epicardial fat; Atrial fibrillation; Hepatic steatosis; Subsistance population (search for similar items in EconPapers)
Date: 2025-09
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Published in American Journal of Preventive Cardiology, 2025, 23, pp.101271. ⟨10.1016/j.ajpc.2025.101271⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-05229534

DOI: 10.1016/j.ajpc.2025.101271

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