Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon

Jacob E. Aronoff, Carrie L. Jenkins, Angela R. Garcia, Stephanie V. Koebele, Suhail Ghafoor, Kate L. Woolard, Mia Charifson, Ivan Maldonado Suarez, Daniel Eid Rodriguez, Bret A. Beheim, Daniel K. Cummings, Paul L. Hooper, Thomas K. Kraft, Kenneth Buetow, Caleb E. Finch, Maximilien Franck, Alan A. Cohen, Jonathan Stieglitz, Michael Gurven, Hillard Kaplan and Benjamin C. Trumble
Additional contact information
Jacob E. Aronoff: ASU - Arizona State University [Tempe]
Carrie L. Jenkins: ASU - Arizona State University [Tempe]
Angela R. Garcia: ASU - Arizona State University [Tempe]
Stephanie V. Koebele: ASU - Arizona State University [Tempe]
Suhail Ghafoor: ASU - Arizona State University [Tempe]
Kate L. Woolard: ASU - Arizona State University [Tempe]
Mia Charifson: NYU - New York University [New York] - NYU - NYU System
Ivan Maldonado Suarez: UMSS - Universidad Mayor de San Simón [Cochabamba, Bolivie]
Daniel Eid Rodriguez: UMSS - Universidad Mayor de San Simón [Cochabamba, Bolivie]
Bret A. Beheim: Max Planck Society
Daniel K. Cummings: Chapman University
Paul L. Hooper: Unknown, Chapman University
Thomas K. Kraft: University of Utah
Kenneth Buetow: ASU - Arizona State University [Tempe]
Caleb E. Finch: USC - University of Southern California
Maximilien Franck: CIREQ - Centre Interuniversitaire de Recherche en Economie Quantitative
Alan A. Cohen: Columbia University [New York]
Jonathan Stieglitz: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, IAST - Institute for Advanced Study in Toulouse
Michael Gurven: UC Santa Barbara - University of California [Santa Barbara] - UC - University of California
Hillard Kaplan: Chapman University
Benjamin C. Trumble: ASU - Arizona State University [Tempe]

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Abstract: An increase in chronic systemic inflammation in later life, termed inflammaging, is implicated in health risk. However, it is unclear whether inflammaging develops in all human populations, or if it is the product of environmental mismatch. We assessed inflammaging in Tsimane forager-horticulturalists of the Bolivian Amazon, using serum cytokines in a primarily cross-sectional sample (1134 samples from n = 714 individuals, age 39–94, 51.3% female). IL-6 was positively associated with age (β = 0.013, p < 0.01). However, other pro-inflammatory markers, including IL-1β and TNF-α, did not increase with age (β = −0.005 and β = −0.001, respectively). We then compared the Moseten, a neighbouring population that has experienced greater market integration (423 samples from n = 380 individuals, age 39–85, 48.2% female). The Moseten also showed a positive age association for IL-6 that attenuated at later ages (age β = 0.025, p < 0.01; age2 β = −0.001, p < 0.05). Further, IL-1β and TNF-α were both positively associated with age (β = 0.021, p < 0.05 and β = 0.011, p < 0.01, respectively). Our results demonstrate minimal inflammaging in the Tsimane, highlighting variation across populations in this age-related process. They also suggest that inflammaging is exacerbated by lifestyle shifts.

Date: 2025-08
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Published in Proceedings of the Royal Society B: Biological Sciences, 2025, 292 (2053), pp.20251111. ⟨10.1098/rspb.2025.1111⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-05227446

DOI: 10.1098/rspb.2025.1111

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