lynx   »   [go: up one dir, main page]
ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Chem. Neurosci. 2015, 6, 1, 16-26
RETURN TO ISSUEPREVReviewNEXT

A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature

View Author Information
†Department of Anatomy and Neurobiology and ‡Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States
§ Department of Psychology, University of Colorado, Denver, Colorado 80015, United States
*Mailing address: Department of Psychology, University of Colorado, Campus Box 173, PO Box 173364, Denver, CO 80217-3364. E-mail: [email protected]
Cite this: ACS Chem. Neurosci. 2015, 6, 1, 16–26
Publication Date (Web):December 10, 2014
https://doi.org/10.1021/cn500255p
Copyright © 2014 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
1496
Altmetric
-
Citations
76
LEARN ABOUT THESE METRICS
Read OnlinePDF (2 MB)
Get e-Alerts
SUBJECTS:

Abstract

Abstract Image

Survival is dictated by an organism’s fitness in approaching positive stimuli and avoiding harm. While a rich literature outlines a role for mesolimbic dopamine in reward and appetitive behaviors, dopamine’s involvement in aversion and avoidance behaviors remains controversial. Debate surrounding dopamine’s function in the processing of negative stimuli likely stems from conflicting results reported by single-unit electrophysiological studies. Indeed, a number of studies suggest that midbrain dopaminergic cells are inhibited by the presentation of negative or fearful stimuli, while others report no change, or even an increase, in their activity. These disparate results may be due to population heterogeneity. Recent evidence demonstrates that midbrain dopamine neurons are heterogeneous in their projection targets, responses to environmental stimuli, pharmacology, and influences on motivated behavior. Thus, in order to assemble an accurate account of dopamine function during aversive stimulus experience and related behavior, it is necessary to examine the functional output of dopamine neural activity at mesolimbic terminal regions. This Review presents a growing body of evidence that dopamine release in the nucleus accumbens encodes not only reward, but also aversion. For example, our laboratory recently utilized fast-scan cyclic voltammetry to show that real-time changes in accumbal dopamine release are detected when animals are presented with predictors of aversion and its avoidance. These data, along with other reports, support a considerably more nuanced view of dopamine neuron function, wherein accumbal dopamine release is differentially modulated by positive and negative affective stimuli to promote adaptive behaviors.

KEYWORDS:

Cited By

This article is cited by 76 publications.

  1. Maria A. Mikhailova, Alex L. Deal, Valentina P. Grinevich, Keith D. Bonin, Raul R. Gainetdinov, Evgeny A. Budygin. Real-Time Accumbal Dopamine Response to Negative Stimuli: Effects of Ethanol. ACS Chemical Neuroscience 2019, 10 (4) , 1986-1991. https://doi.org/10.1021/acschemneuro.8b00272
  2. Jin W. Park, Rohan V. Bhimani, and Jinwoo Park . Noradrenergic Modulation of Dopamine Transmission Evoked by Electrical Stimulation of the Locus Coeruleus in the Rat Brain. ACS Chemical Neuroscience 2017, 8 (9) , 1913-1924. https://doi.org/10.1021/acschemneuro.7b00078
  3. Huan H. Cao, Nako Nakatsuka, Wei-Ssu Liao, Andrew C. Serino, Sarawut Cheunkar, Hongyan Yang, Paul S. Weiss, and Anne M. Andrews . Advancing Biocapture Substrates via Chemical Lift-Off Lithography. Chemistry of Materials 2017, 29 (16) , 6829-6839. https://doi.org/10.1021/acs.chemmater.7b01970
  4. Yingliang Xie, Peizhen Wang, Xiaoyan Cui, Lei Liu, Pengcheng Wang, Shimei Jing, Qi Liu, Yuting Wang, Shiqiang Wang. Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D1 signaling. Behavioural Brain Research 2022, 416 , 113540. https://doi.org/10.1016/j.bbr.2021.113540
  5. Haena Kim, Namrata Nanavaty, Humza Ahmed, Vani A. Mathur, Brian A. Anderson. Motivational Salience Guides Attention to Valuable and Threatening Stimuli: Evidence from Behavior and Functional Magnetic Resonance Imaging. Journal of Cognitive Neuroscience 2021, 33 (12) , 2440-2460. https://doi.org/10.1162/jocn_a_01769
  6. Leonie Duehlmeyer, Nicholas Parsons, Charles B. Malpas, Robert Hester. Functional connectivity during feedback learning in smokers. Addiction Biology 2021, 23 https://doi.org/10.1111/adb.13109
  7. Zhenni Gao, Xiaojin Liu, Delong Zhang, Ming Liu, Ning Hao. Subcortical structures and visual divergent thinking: a resting-state functional MRI analysis. Brain Structure and Function 2021, 226 (8) , 2617-2627. https://doi.org/10.1007/s00429-021-02355-z
  8. Sohini Dutta, Jasmin Beaver, Carly J. Halcomb, Aaron M. Jasnow. Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear. Neurobiology of Stress 2021, 15 , 100365. https://doi.org/10.1016/j.ynstr.2021.100365
  9. Yukie Kawahara, Yoshinori N Ohnishi, Yoko H Ohnishi, Hiroshi Kawahara, Akinori Nishi. Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues. International Journal of Neuropsychopharmacology 2021, 20 https://doi.org/10.1093/ijnp/pyab067
  10. Xuemian Song, Yiyun Liu, Juncai Pu, Siwen Gui, Xiaogang Zhong, Xiaopeng Chen, Weiyi Chen, Xiang Chen, Yue Chen, Haiyang Wang, Ke Cheng, Libo Zhao, Peng Xie. Transcriptomics Analysis Reveals Shared Pathways in Peripheral Blood Mononuclear Cells and Brain Tissues of Patients With Schizophrenia. Frontiers in Psychiatry 2021, 12 https://doi.org/10.3389/fpsyt.2021.716722
  11. Chencai Wang, Kathleen Van Dyk, Nicholas Cho, Catalina Raymond, Justin Choi, Noriko Salamon, Whitney B. Pope, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Benjamin M. Ellingson. Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI). Brain Imaging and Behavior 2021, 29 https://doi.org/10.1007/s11682-021-00497-6
  12. Conner W. Wallace, Steve C. Fordahl. Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake. Nutrition Research Reviews 2021, 136 , 1-16. https://doi.org/10.1017/S0954422421000196
  13. Erik B. Oleson, Lindsey R. Hamilton, Devan M. Gomez. Cannabinoid Modulation of Dopamine Release During Motivation, Periodic Reinforcement, Exploratory Behavior, Habit Formation, and Attention. Frontiers in Synaptic Neuroscience 2021, 13 https://doi.org/10.3389/fnsyn.2021.660218
  14. Shuyuan Xu, Yuyan Sun, Min Huang, Yanhong Huang, Jing Han, Xuemei Tang, Wei Ren. Emotional State and Feedback-Related Negativity Induced by Positive, Negative, and Combined Reinforcement. Frontiers in Psychology 2021, 12 https://doi.org/10.3389/fpsyg.2021.647263
  15. Alexander F. Hoffman, Eun-Kyung Hwang, Carl R. Lupica. Impairment of Synaptic Plasticity by Cannabis, Δ 9 -THC, and Synthetic Cannabinoids. Cold Spring Harbor Perspectives in Medicine 2021, 11 (5) , a039743. https://doi.org/10.1101/cshperspect.a039743
  16. Pål Kraft, Brage Kraft. Explaining Socioeconomic Disparities in Health Behaviours: A Review of Biopsychological Pathways Involving Stress and Inflammation. Neuroscience & Biobehavioral Reviews 2021, 49 https://doi.org/10.1016/j.neubiorev.2021.05.019
  17. Christina M. Ruiz, Alexa Torrens, Erik Castillo, Christina R. Perrone, Jenny Cevallos, Victoria C. Inshishian, Eden V. Harder, Drew N. Justeson, Marilyn A. Huestis, Vivek Swarup, Daniele Piomelli, Stephen V. Mahler. Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats. Neuropsychopharmacology 2021, 46 (5) , 959-969. https://doi.org/10.1038/s41386-020-00839-w
  18. Thomas J. Everett, Devan M. Gomez, Lindsey R. Hamilton, Erik B. Oleson. Endocannabinoid modulation of dopamine release during reward seeking, interval timing, and avoidance. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2021, 104 , 110031. https://doi.org/10.1016/j.pnpbp.2020.110031
  19. Kate Z. Peters, Erik B. Oleson, Joseph F. Cheer. A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction. Cold Spring Harbor Perspectives in Medicine 2021, 11 (1) , a039305. https://doi.org/10.1101/cshperspect.a039305
  20. Jingyang Su, Zhi Li, Akira Yamashita, Ikue Kusumoto-Yoshida, Takuto Isomichi, Liying Hao, Tomoyuki Kuwaki. Involvement of the Nucleus Accumbens in Chocolate-induced Cataplexy. Scientific Reports 2020, 10 (1) https://doi.org/10.1038/s41598-020-61823-4
  21. Nicolette A. Moya, Margaret K. Tanner, Abigail M. Smith, Aleezah Balolia, Jazmyne K.P. Davis, Kelsey Bonar, Jennifer Jaime, Troy Hubert, Jorge Silva, William Whitworth, Esteban C. Loetz, Sondra T. Bland, Benjamin N. Greenwood. Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling. Neurobiology of Learning and Memory 2020, 176 , 107328. https://doi.org/10.1016/j.nlm.2020.107328
  22. Mahsa Sadeghi-Adl, Mitra-Sadat Sadat-Shirazi, Faezeh Shahini, Ardeshir Akbarabadi, Solmaz Khalifeh, Shokoofeh Borzabadi, Mohammad Nasehi, Mohammad-Reza Zarrindast. The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement. Life Sciences 2020, 260 , 118430. https://doi.org/10.1016/j.lfs.2020.118430
  23. Clarissa C. Parker, Ryan Lusk, Laura M. Saba. Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. Brain Sciences 2020, 10 (10) , 725. https://doi.org/10.3390/brainsci10100725
  24. Jeffrey L. Barr, Ellen M. Unterwald. Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2020, 1867 (9) , 118746. https://doi.org/10.1016/j.bbamcr.2020.118746
  25. Lars Freudenmacher, Arndt Twickel, Wolfgang Walkowiak. The habenula as an evolutionary conserved link between basal ganglia, limbic, and sensory systems—A phylogenetic comparison based on anuran amphibians. Journal of Comparative Neurology 2020, 528 (5) , 705-728. https://doi.org/10.1002/cne.24777
  26. Kenneth Blum, David Baron, Thomas McLaughlin, Mark S. Gold. Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS). Journal of the Neurological Sciences 2020, 411 , 116733. https://doi.org/10.1016/j.jns.2020.116733
  27. B. Jill Venton, Dana J. DiScenza. Voltammetry. 2020,,, 27-50. https://doi.org/10.1016/B978-0-12-821203-5.00004-X
  28. Priscila Cervini, Isabela A. Mattioli, Éder T. G. Cavalheiro. Developing a screen-printed graphite–polyurethane composite electrode modified with gold nanoparticles for the voltammetric determination of dopamine. RSC Advances 2019, 9 (72) , 42306-42315. https://doi.org/10.1039/C9RA09046K
  29. Milene Cristina de Carvalho, Rebeca Machado de Figueiredo, Norberto Cysne Coimbra, Christie Ramos Andrade Leite-Panissi, Maria Angélica de Souza Silva, Joseph P Huston, Claudia Mattern, Marcus Lira Brandão. Intranasal dopamine attenuates fear responses induced by electric shock to the foot and by electrical stimulation of the dorsal periaqueductal gray matter. Journal of Psychopharmacology 2019, 33 (12) , 1524-1532. https://doi.org/10.1177/0269881119862527
  30. Michael AP Bloomfield, Robert A McCutcheon, Matthew Kempton, Tom P Freeman, Oliver Howes. The effects of psychosocial stress on dopaminergic function and the acute stress response. eLife 2019, 8 https://doi.org/10.7554/eLife.46797
  31. Xiangdang Shi, Jeffrey L. Barr, Eva von Weltin, Cassandra Wolsh, Ellen M. Unterwald. Differential Roles of Accumbal GSK3 β in Cocaine versus Morphine-Induced Place Preference, U50,488H-Induced Place Aversion, and Object Memory. Journal of Pharmacology and Experimental Therapeutics 2019, 371 (2) , 339-347. https://doi.org/10.1124/jpet.119.259283
  32. A. V. Latanov, V. A. Korshunov, V. I. Maiorov, A. N. Serkov. Serotonin and Dopamine in Biological Models of Depression. Neuroscience and Behavioral Physiology 2019, 49 (8) , 987-995. https://doi.org/10.1007/s11055-019-00828-7
  33. Nora D. Volkow, Michael Michaelides, Ruben Baler. The Neuroscience of Drug Reward and Addiction. Physiological Reviews 2019, 99 (4) , 2115-2140. https://doi.org/10.1152/physrev.00014.2018
  34. V. I. Maiorov. The Functions of Dopamine in Operant Conditioned Reflexes. Neuroscience and Behavioral Physiology 2019, 49 (7) , 887-893. https://doi.org/10.1007/s11055-019-00815-y
  35. Mariya V. Cherkasova, Jeffrey C. Corrow, Alisdair Taylor, Shanna C. Yeung, Jacob L. Stubbs, Martin J. McKeown, Silke Appel-Cresswell, A. Jon Stoessl, Jason J.S. Barton. Dopamine replacement remediates risk aversion in Parkinson's disease in a value-independent manner. Parkinsonism & Related Disorders 2019, 66 , 189-194. https://doi.org/10.1016/j.parkreldis.2019.08.014
  36. Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami, Yusaku Nakabeppu. 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes. Progress in Neurobiology 2019, 180 , 101613. https://doi.org/10.1016/j.pneurobio.2019.04.002
  37. Benjamin N. Greenwood. The role of dopamine in overcoming aversion with exercise. Brain Research 2019, 1713 , 102-108. https://doi.org/10.1016/j.brainres.2018.08.030
  38. Ronny N. Gentry, Douglas R. Schuweiler, Matthew R. Roesch. Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability. Brain Research 2019, 1713 , 80-90. https://doi.org/10.1016/j.brainres.2018.10.008
  39. Kevin Lloyd, Peter Dayan. Pavlovian-instrumental interactions in active avoidance: The bark of neutral trials. Brain Research 2019, 1713 , 52-61. https://doi.org/10.1016/j.brainres.2018.10.011
  40. Caitlin M. Vander Weele, Cody A. Siciliano, Kay M. Tye. Dopamine tunes prefrontal outputs to orchestrate aversive processing. Brain Research 2019, 1713 , 16-31. https://doi.org/10.1016/j.brainres.2018.11.044
  41. Kimberly C. Thibeault, Munir Gunes Kutlu, Christina Sanders, Erin S. Calipari. Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction. Brain Research 2019, 1713 , 1-15. https://doi.org/10.1016/j.brainres.2018.12.024
  42. Guihua Xiao, Jungyoon Kim, Xinxia Cai, Tianhong Cui. Shrink-Induced Highly Sensitive Dopamine Sensor Based On Self-Assembly Graphene on Microelectrode. 2019,,, 1120-1123. https://doi.org/10.1109/TRANSDUCERS.2019.8808235
  43. Ye-Ha Jung, Joon Hwan Jang, Dasom Lee, Yoobin Choi, Soo-Hee Choi, Do-Hyung Kang. Relationships Between Catecholamine Levels and Stress or Intelligence. Neurochemical Research 2019, 44 (5) , 1192-1200. https://doi.org/10.1007/s11064-019-02762-z
  44. Michael Silkstone, Stefan M. Brudzynski. Intracerebral injection of R-(-)-Apomorphine into the nucleus accumbens decreased carbachol-induced 22-kHz ultrasonic vocalizations in rats. Behavioural Brain Research 2019, 364 , 264-273. https://doi.org/10.1016/j.bbr.2019.01.044
  45. Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Cen. HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure. Neuropharmacology 2019, 148 , 377-393. https://doi.org/10.1016/j.neuropharm.2017.10.001
  46. Xinjian Zhang, Taku Nagai, Rijwan Uddin Ahammad, Keisuke Kuroda, Shinichi Nakamuta, Takashi Nakano, Naoto Yukinawa, Yasuhiro Funahashi, Yukie Yamahashi, Mutsuki Amano, Junichiro Yoshimoto, Kiyofumi Yamada, Kozo Kaibuchi. Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochemistry International 2019, 122 , 8-18. https://doi.org/10.1016/j.neuint.2018.10.008
  47. Caitlin A. Orsini, Sara C. Heshmati, Tyler S. Garman, Shannon C. Wall, Jennifer L. Bizon, Barry Setlow. Contributions of medial prefrontal cortex to decision making involving risk of punishment. Neuropharmacology 2018, 139 , 205-216. https://doi.org/10.1016/j.neuropharm.2018.07.018
  48. Carl R. Lupica, Alexander F. Hoffman. Cannabinoid disruption of learning mechanisms involved in reward processing. Learning & Memory 2018, 25 (9) , 435-445. https://doi.org/10.1101/lm.046748.117
  49. Shenghong Yang, Xiaohan Sun, Zhaoyan Wang, Xiayan Wang, Guangsheng Guo, Qiaosheng Pu. One-step facile green synthesis of a highly fluorescent molecule through a way towards carbon dots and detection of dopamine based on in-situ formation of silver nanoparticles. Sensors and Actuators B: Chemical 2017, 253 , 752-758. https://doi.org/10.1016/j.snb.2017.06.137
  50. Kanta Terao, Makoto Mizunami. Roles of dopamine neurons in mediating the prediction error in aversive learning in insects. Scientific Reports 2017, 7 (1) https://doi.org/10.1038/s41598-017-14473-y
  51. Ryne C. Ramaker, Kevin M. Bowling, Brittany N. Lasseigne, Megan H. Hagenauer, Andrew A. Hardigan, Nicholas S. Davis, Jason Gertz, Preston M. Cartagena, David M. Walsh, Marquis P. Vawter, Edward G. Jones, Alan F. Schatzberg, Jack D. Barchas, Stanley J. Watson, Blynn G. Bunney, Huda Akil, William E. Bunney, Jun Z. Li, Sara J. Cooper, Richard M. Myers. Post-mortem molecular profiling of three psychiatric disorders. Genome Medicine 2017, 9 (1) https://doi.org/10.1186/s13073-017-0458-5
  52. Nuket Gocmen Mas, Harun Muayad Said, Murat Tosun, Nilufer Yonguc, Yasemin Soysal, Hamit Selim Karabekir. Anatomical, Biological, and Surgical Features of Basal Ganglia. 2017,,https://doi.org/10.5772/intechopen.68851
  53. Junchol Park, Bita Moghaddam. Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons. eLife 2017, 6 https://doi.org/10.7554/eLife.30056
  54. Vasco A Conceição, Ângelo Dias, Ana C Farinha, Tiago V Maia. Premonitory urges and tics in Tourette syndrome: computational mechanisms and neural correlates. Current Opinion in Neurobiology 2017, 46 , 187-199. https://doi.org/10.1016/j.conb.2017.08.009
  55. Xiuling Nie, Yu Sun, Suiren Wan, Hui Zhao, Renyuan Liu, Xueping Li, Sichu Wu, Zuzana Nedelska, Jakub Hort, Zhao Qing, Yun Xu, Bing Zhang. Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer’s Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach. Frontiers in Neurology 2017, 8 https://doi.org/10.3389/fneur.2017.00399
  56. Mitsuko Watabe-Uchida, Neir Eshel, Naoshige Uchida. Neural Circuitry of Reward Prediction Error. Annual Review of Neuroscience 2017, 40 (1) , 373-394. https://doi.org/10.1146/annurev-neuro-072116-031109
  57. Katherine Stuhrman West, Aaron G. Roseberry. Neuropeptide-Y alters VTA dopamine neuron activity through both pre- and postsynaptic mechanisms. Journal of Neurophysiology 2017, 118 (1) , 625-633. https://doi.org/10.1152/jn.00879.2016
  58. Sebastian D. McBride, Matthew O. Parker, Kirsty Roberts, Andrew Hemmings. Applied neurophysiology of the horse; implications for training, husbandry and welfare. Applied Animal Behaviour Science 2017, 190 , 90-101. https://doi.org/10.1016/j.applanim.2017.02.014
  59. Olga Dona, Michael D. Noseworthy, Carol DeMatteo, John F. Connolly, . Fractal Analysis of Brain Blood Oxygenation Level Dependent (BOLD) Signals from Children with Mild Traumatic Brain Injury (mTBI). PLOS ONE 2017, 12 (1) , e0169647. https://doi.org/10.1371/journal.pone.0169647
  60. He Liu, Dipesh Chaudhury. Understanding Mood Disorders Using Electrophysiology and Circuit Breaking. 2017,,, 343-370. https://doi.org/10.1007/978-3-319-57363-2_14
  61. J E LeDoux, J Moscarello, R Sears, V Campese. The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm. Molecular Psychiatry 2017, 22 (1) , 24-36. https://doi.org/10.1038/mp.2016.166
  62. Ying Han, Lin Lu. The Other Face of the Nucleus Accumbens: Aversion. Neuroscience Bulletin 2016, 32 (6) , 569-571. https://doi.org/10.1007/s12264-016-0051-8
  63. Delaney Smith, Riley Smith, Douglas Misquitta. Neuroimaging and Violence. Psychiatric Clinics of North America 2016, 39 (4) , 579-597. https://doi.org/10.1016/j.psc.2016.07.006
  64. Ronny N. Gentry, Brian Lee, Matthew R. Roesch. Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance. Nature Communications 2016, 7 (1) https://doi.org/10.1038/ncomms13154
  65. Tamara L. Doremus-Fitzwater, Linda P. Spear. Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals. Neuroscience & Biobehavioral Reviews 2016, 70 , 121-134. https://doi.org/10.1016/j.neubiorev.2016.08.015
  66. Hideyuki Matsumoto, Ju Tian, Naoshige Uchida, Mitsuko Watabe-Uchida. Midbrain dopamine neurons signal aversion in a reward-context-dependent manner. eLife 2016, 5 https://doi.org/10.7554/eLife.17328
  67. Giorgio Bergamini, Hannes Sigrist, Boris Ferger, Nicolas Singewald, Erich Seifritz, Christopher R. Pryce. Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies. Neuropharmacology 2016, 109 , 306-319. https://doi.org/10.1016/j.neuropharm.2016.03.048
  68. Enrica L. Santarcangelo, Lucia Briscese, Simone Capitani, Paolo Orsini, Maurizio Varanini, Bruno Rossi, Maria C. Carboncini. Blink reflex in subjects with different hypnotizability: New findings for an old debate. Physiology & Behavior 2016, 163 , 288-293. https://doi.org/10.1016/j.physbeh.2016.05.021
  69. Praneeth Namburi, Ream Al-Hasani, Gwendolyn G Calhoon, Michael R Bruchas, Kay M Tye. Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology 2016, 41 (7) , 1697-1715. https://doi.org/10.1038/npp.2015.358
  70. Basma Radwan, He Liu, Dipesh Chaudhury. Regulation and Modulation of Depression-Related Behaviours: Role of Dopaminergic Neurons. 2016,,, 147-190. https://doi.org/10.1007/978-3-319-46437-4_8
  71. Francesco Rigoli, Giovanni Pezzulo, Raymond J. Dolan. Prospective and Pavlovian mechanisms in aversive behaviour. Cognition 2016, 146 , 415-425. https://doi.org/10.1016/j.cognition.2015.10.017
  72. Dipesh Chaudhury, He Liu, Ming-Hu Han. Neuronal correlates of depression. Cellular and Molecular Life Sciences 2015, 72 (24) , 4825-4848. https://doi.org/10.1007/s00018-015-2044-6
  73. Nicole M. Enman, Kayti Arthur, Sara J. Ward, Shane A. Perrine, Ellen M. Unterwald. Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder. Biological Psychiatry 2015, 78 (12) , 871-879. https://doi.org/10.1016/j.biopsych.2015.04.024
  74. Caitlin A. Orsini, David E. Moorman, Jared W. Young, Barry Setlow, Stan B. Floresco. Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models. Neuroscience & Biobehavioral Reviews 2015, 58 , 147-167. https://doi.org/10.1016/j.neubiorev.2015.04.009
  75. Bariş O. Yildirim, Jan J.L. Derksen. Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity. Psychiatry Research 2015, 229 (3) , 633-677. https://doi.org/10.1016/j.psychres.2015.07.005
  76. Thomas Vaessen, Dennis Hernaus, Inez Myin-Germeys, Thérèse van Amelsvoort. The dopaminergic response to acute stress in health and psychopathology: A systematic review. Neuroscience & Biobehavioral Reviews 2015, 56 , 241-251. https://doi.org/10.1016/j.neubiorev.2015.07.008

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE
Лучший частный хостинг