| 19.11.2021 | 20:45 | Dundalk FC | - | Derry City | 1:2 (1:1) | |
| 20:45 | Finn Harps | - | Longford Town | 5:0 (2:0) | ||
| 20:45 | Shamrock Rovers | - | Drogheda United | 2:1 (0:1) | ||
| 20:45 | Sligo Rovers | - | Bohemian FC | 1:1 (1:0) | ||
| 20:45 | Waterford FC | - | St Patrick's Athletic | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Shamrock Rovers | 36 | 24 | 6 | 6 | 59:28 | 31 | 78 |
| 2 |
|
St Patrick's Athletic | 36 | 18 | 8 | 10 | 56:42 | 14 | 62 |
| 3 |
|
Sligo Rovers | 36 | 16 | 9 | 11 | 43:32 | 11 | 57 |
| 4 |
|
Derry City | 36 | 14 | 12 | 10 | 49:42 | 7 | 54 |
| 5 |
|
Bohemian FC | 36 | 14 | 10 | 12 | 60:46 | 14 | 52 |
| 6 |
|
Dundalk FC | 36 | 13 | 9 | 14 | 44:46 | -2 | 48 |
| 7 |
|
Drogheda United | 36 | 12 | 8 | 16 | 45:43 | 2 | 44 |
| 8 |
|
Finn Harps | 36 | 11 | 11 | 14 | 44:52 | -8 | 44 |
| 9 |
|
Waterford FC | 36 | 12 | 6 | 18 | 36:56 | -20 | 42 |
| 10 |
|
Longford Town | 36 | 2 | 9 | 25 | 22:71 | -49 | 15 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |