| 13.02.2022 | 20:00 | Leones FC | - | Tigres FC | 3:1 (1:0) | |
| 21:00 | Atlético FC | - | Fortaleza FC | 2:2 (1:2) | ||
| 21:00 | Llaneros FC | - | Boyacá Chicó | 1:2 (1:0) | ||
| 21:00 | Real Santander | - | Barranquilla FC | 2:3 (2:1) | ||
| 14.02.2022 | 21:00 | Orsomarso SC | - | Boca Juniors de Cali | 2:0 (2:0) | |
| 15.02.2022 | 00:00 | Bogotá FC | - | Valledupar FC | 2:1 (0:1) | |
| 02:00 | Real Cartagena | - | Atlético Huila | 1:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boyacá Chicó | 4 | 3 | 1 | 0 | 5:2 | 3 | 10 |
| 2 |
|
Leones FC | 4 | 3 | 0 | 1 | 6:3 | 3 | 9 |
| 3 |
|
Real Cartagena | 4 | 2 | 2 | 0 | 6:3 | 3 | 8 |
| 4 |
|
Bogotá FC | 4 | 2 | 2 | 0 | 5:3 | 2 | 8 |
| 5 |
|
Orsomarso SC | 4 | 2 | 1 | 1 | 5:3 | 2 | 7 |
| 6 |
|
Atlético FC | 4 | 1 | 3 | 0 | 4:3 | 1 | 6 |
| 7 |
|
Fortaleza FC | 4 | 1 | 2 | 1 | 8:7 | 1 | 5 |
| 8 |
|
Real Santander | 4 | 1 | 1 | 2 | 5:6 | -1 | 4 |
| 9 |
|
Barranquilla FC | 3 | 1 | 1 | 1 | 3:4 | -1 | 4 |
| 10 |
|
Valledupar FC | 4 | 1 | 1 | 2 | 2:3 | -1 | 4 |
| 11 |
|
Deportes Quindío | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
| 12 |
|
Atlético Huila | 3 | 0 | 2 | 1 | 2:4 | -2 | 2 |
| 13 |
|
Tigres FC | 4 | 0 | 2 | 2 | 3:6 | -3 | 2 |
| 14 |
|
Llaneros FC | 3 | 0 | 1 | 2 | 1:3 | -2 | 1 |
| 15 |
|
Boca Juniors de Cali | 4 | 0 | 1 | 3 | 2:6 | -4 | 1 |
| Nächste Runde |