| 21/01/2011 | 19:45 | FC Sochaux | - | Paris FC | 2:1 (1:0) | |
| 22/01/2011 | 13:15 | SO Chambéry | - | Stade Brestois 29 | 4:3 (0:0, 0:0, 1:1) pso | |
| 14:00 | Clermont Foot Auvergne 63 | - | Stade de Reims | 1:3 (1:3) | ||
| 16:00 | Nîmes Olympique | - | AS Nancy Lorraine | 1:2 (1:0, 1:1) aet | ||
| 16:00 | Angers SCO | - | Girondins Bordeaux | 1:0 (0:0) | ||
| 16:00 | US Boulogne | - | JA Drancy | 0:1 (0:0) | ||
| 17:00 | FC Nantes | - | US Raon-l'Etape | 2:1 (1:0) | ||
| 17:00 | US Quevilly | - | FC Martigues | 3:5 (0:1, 1:1, 1:1) pso | ||
| 17:30 | Vendée Fontenay | - | FC Lorient | 0:1 (0:0, 0:0) aet | ||
| 18:30 | AS Cherbourg | - | Le Mans FC | 0:1 (0:1) | ||
| 19:45 | RC Strasbourg | - | Évian Thonon Gaillard | 1:0 (1:0) | ||
| 23/01/2011 | 13:45 | FC Vaulx-en-Velin | - | Stade Rennais | 0:2 (0:0) | |
| 14:00 | CS Sedan | - | FC Metz | 0:1 (0:1) | ||
| 16:00 | SU Agen | - | Paris Saint-Germain | 2:3 (1:1) | ||
| 16:30 | Lille OSC | - | ES Wasquehal | 1:0 (1:0) | ||
| 19:45 | OGC Nice | - | Olympique Lyonnais | 1:0 (0:0, 0:0) aet |