| 30/10/2022 | 18:00 | Manta | - | Olmedo | 2:1 (1:1) | |
| 18:00 | Búhos ULVR | - | Atlético Santo Domingo | 1:1 (0:0) | ||
| 20:30 | Independiente Juniors | - | América de Quito | 1:1 (1:1) | ||
| 20:30 | Libertad de Loja | - | Imbabura | 2:0 (1:0) | ||
| 31/10/2022 | 20:30 | El Nacional | - | Chacaritas FC | 2:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
El Nacional | 36 | 18 | 9 | 9 | 54:37 | 17 | 63 |
| 2 |
|
Independiente Juniors | 36 | 15 | 11 | 10 | 44:33 | 11 | 56 |
| 3 |
|
Libertad de Loja | 36 | 15 | 11 | 10 | 42:38 | 4 | 56 |
| 4 |
|
América de Quito | 36 | 13 | 15 | 8 | 41:31 | 10 | 54 |
| 5 |
|
Imbabura | 36 | 13 | 8 | 15 | 47:51 | -4 | 47 |
| 6 |
|
Chacaritas FC | 36 | 11 | 10 | 15 | 30:38 | -8 | 43 |
| 7 |
|
Búhos ULVR | 36 | 9 | 15 | 12 | 33:38 | -5 | 42 |
| 8 |
|
Manta | 36 | 10 | 12 | 14 | 29:39 | -10 | 42 |
| 9 |
|
Atlético Santo Domingo | 36 | 9 | 12 | 15 | 31:36 | -5 | 39 |
| 10 |
|
Olmedo | 36 | 10 | 11 | 15 | 33:43 | -10 | 38 |
| Promotion | |
| Relegation |