| 1st(1st leg) | VfB Stuttgart | - | Dinamo Moskva | 2:0 (0:0) | ||
| 2nd (2nd leg) | Dinamo Moskva | - | VfB Stuttgart | 1:1 (0:0) | ||
| 1st(1st leg): 22/08/2012 17:15 | 2nd (2nd leg): 28/08/2012 17:00 | Winner: VfB Stuttgart | ||||
| 1st(1st leg) | Anzhi Makhachkala | - | AZ Alkmaar | 1:0 (0:0) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | Anzhi Makhachkala | 0:5 (0:2) | ||
| 1st(1st leg): 23/08/2012 17:00 | 2nd (2nd leg): 30/08/2012 20:00 | Winner: Anzhi Makhachkala | ||||
| 1st(1st leg) | Neftçi PFK | - | APOEL Nikosia | 1:1 (0:0) | ||
| 2nd (2nd leg) | APOEL Nikosia | - | Neftçi PFK | 1:3 (1:2) | ||
| 1st(1st leg): 23/08/2012 17:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: Neftçi PFK | ||||
| 1st(1st leg) | Tromsø IL | - | Partizan | 3:2 (1:1) | ||
| 2nd (2nd leg) | Partizan | - | Tromsø IL | 1:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 17:30 | 2nd (2nd leg): 30/08/2012 19:45 | Winner: Partizan | ||||
| 1st(1st leg) | FK Ekranas | - | FC Steaua Bucureşti | 0:2 (0:1) | ||
| 2nd (2nd leg) | FC Steaua Bucureşti | - | FK Ekranas | 3:0 (2:0) | ||
| 1st(1st leg): 23/08/2012 17:45 | 2nd (2nd leg): 30/08/2012 18:30 | Winner: FC Steaua Bucureşti | ||||
| 1st(1st leg) | Slovan Liberec | - | Dnipro Dnipropetrovsk | 2:2 (0:1) | ||
| 2nd (2nd leg) | Dnipro Dnipropetrovsk | - | Slovan Liberec | 4:2 (1:0) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 17:00 | Winner: Dnipro Dnipropetrovsk | ||||
| 1st(1st leg) | FC Sheriff | - | Olympique Marseille | 1:2 (1:1) | ||
| 2nd (2nd leg) | Olympique Marseille | - | FC Sheriff | 0:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 19:30 | Winner: Olympique Marseille | ||||
| 1st(1st leg) | Molde FK | - | sc Heerenveen | 2:0 (1:0) | ||
| 2nd (2nd leg) | sc Heerenveen | - | Molde FK | 1:2 (0:0) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: Molde FK | ||||
| 1st(1st leg) | Legia Warszawa | - | Rosenborg BK | 1:1 (1:0) | ||
| 2nd (2nd leg) | Rosenborg BK | - | Legia Warszawa | 2:1 (0:1) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: Rosenborg BK | ||||
| 1st(1st leg) | Atromitos | - | Newcastle United | 1:1 (1:1) | ||
| 2nd (2nd leg) | Newcastle United | - | Atromitos | 1:0 (1:0) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 20:00 | Winner: Newcastle United | ||||
| 1st(1st leg) | AIK Solna | - | CSKA Moskva | 0:1 (0:0) | ||
| 2nd (2nd leg) | CSKA Moskva | - | AIK Solna | 0:2 (0:1) | ||
| 1st(1st leg): 23/08/2012 18:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: AIK Solna | ||||
| 1st(1st leg) | FC Luzern | - | KRC Genk | 2:1 (1:1) | ||
| 2nd (2nd leg) | KRC Genk | - | FC Luzern | 2:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 18:30 | 2nd (2nd leg): 30/08/2012 19:00 | Winner: KRC Genk | ||||
| 1st(1st leg) | Dinamo Bucureşti | - | Metalist Kharkiv | 0:2 (0:1) | ||
| 2nd (2nd leg) | Metalist Kharkiv | - | Dinamo Bucureşti | 2:1 (1:0) | ||
| 1st(1st leg): 23/08/2012 18:30 | 2nd (2nd leg): 30/08/2012 19:00 | Winner: Metalist Kharkiv | ||||
| 1st(1st leg) | Bursaspor | - | FC Twente | 3:1 (1:1) | ||
| 2nd (2nd leg) | FC Twente | - | Bursaspor | 4:1 (1:1, 3:1) aet | ||
| 1st(1st leg): 23/08/2012 18:30 | 2nd (2nd leg): 30/08/2012 20:00 | Winner: FC Twente | ||||
| 1st(1st leg) | Trabzonspor | - | Videoton FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Videoton FC | - | Trabzonspor | 4:2 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 23/08/2012 19:00 | 2nd (2nd leg): 30/08/2012 19:30 | Winner: Videoton FC | ||||
| 1st(1st leg) | F91 Dudelange | - | Hapoel Tel Aviv | 1:3 (1:3) | ||
| 2nd (2nd leg) | Hapoel Tel Aviv | - | F91 Dudelange | 4:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 19:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: Hapoel Tel Aviv | ||||
| 1st(1st leg) | Feyenoord | - | AC Sparta Praha | 2:2 (0:2) | ||
| 2nd (2nd leg) | AC Sparta Praha | - | Feyenoord | 2:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 19:00 | 2nd (2nd leg): 30/08/2012 18:30 | Winner: AC Sparta Praha | ||||
| 1st(1st leg) | FC Midtjylland | - | BSC Young Boys | 0:3 (0:1) | ||
| 2nd (2nd leg) | BSC Young Boys | - | FC Midtjylland | 0:2 (0:0) | ||
| 1st(1st leg): 23/08/2012 19:15 | 2nd (2nd leg): 30/08/2012 18:30 | Winner: BSC Young Boys | ||||
| 1st(1st leg) | Sporting Lokeren | - | Viktoria Plzeň | 2:1 (1:1) | ||
| 2nd (2nd leg) | Viktoria Plzeň | - | Sporting Lokeren | 1:0 (1:0) | ||
| 1st(1st leg): 23/08/2012 19:30 | 2nd (2nd leg): 30/08/2012 19:15 | Winner: Viktoria Plzeň | ||||
| 1st(1st leg) | Debreceni VSC | - | Club Brugge KV | 0:3 (0:0) | ||
| 2nd (2nd leg) | Club Brugge KV | - | Debreceni VSC | 4:1 (1:1) | ||
| 1st(1st leg): 23/08/2012 19:30 | 2nd (2nd leg): 30/08/2012 19:30 | Winner: Club Brugge KV | ||||
| 1st(1st leg) | PAOK Saloniki | - | Rapid Wien | 2:1 (0:1) | ||
| 2nd (2nd leg) | Rapid Wien | - | PAOK Saloniki | 3:0 (1:0) | ||
| 1st(1st leg): 23/08/2012 19:35 | 2nd (2nd leg): 30/08/2012 19:45 | Winner: Rapid Wien | ||||
| 1st(1st leg) | Heart of Midlothian | - | Liverpool FC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Liverpool FC | - | Heart of Midlothian | 1:1 (0:0) | ||
| 1st(1st leg): 23/08/2012 19:45 | 2nd (2nd leg): 30/08/2012 20:05 | Winner: Liverpool FC | ||||
| 1st(1st leg) | Śląsk Wrocław | - | Hannover 96 | 3:5 (1:3) | ||
| 2nd (2nd leg) | Hannover 96 | - | Śląsk Wrocław | 5:1 (2:1) | ||
| 1st(1st leg): 23/08/2012 19:45 | 2nd (2nd leg): 30/08/2012 19:45 | Winner: Hannover 96 | ||||
| 1st(1st leg) | Motherwell FC | - | Levante UD | 0:2 (0:1) | ||
| 2nd (2nd leg) | Levante UD | - | Motherwell FC | 1:0 (0:0) | ||
| 1st(1st leg): 23/08/2012 19:45 | 2nd (2nd leg): 30/08/2012 19:45 | Winner: Levante UD | ||||
| 1st(1st leg) | FC Vaslui | - | Inter | 0:2 (0:1) | ||
| 2nd (2nd leg) | Inter | - | FC Vaslui | 2:2 (0:1) | ||
| 1st(1st leg): 23/08/2012 19:45 | 2nd (2nd leg): 30/08/2012 19:45 | Winner: Inter | ||||
| 1st(1st leg) | FK Zeta | - | PSV Eindhoven | 0:5 (0:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | FK Zeta | 9:0 (5:0) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | AC Horsens | - | Sporting CP | 1:1 (1:0) | ||
| 2nd (2nd leg) | Sporting CP | - | AC Horsens | 5:0 (2:0) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 20:30 | Winner: Sporting CP | ||||
| 1st(1st leg) | Athletic Club | - | HJK Helsinki | 6:0 (3:0) | ||
| 2nd (2nd leg) | HJK Helsinki | - | Athletic Club | 3:3 (1:0) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 18:00 | Winner: Athletic Club | ||||
| 1st(1st leg) | ND Mura 05 | - | Lazio Roma | 0:2 (0:1) | ||
| 2nd (2nd leg) | Lazio Roma | - | ND Mura 05 | 3:1 (2:0) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 20:00 | Winner: Lazio Roma | ||||
| 1st(1st leg) | Crvena Zvezda | - | Girondins Bordeaux | 0:0 (0:0) | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | Crvena Zvezda | 3:2 (0:1) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 19:30 | Winner: Girondins Bordeaux | ||||
| 1st(1st leg) | CS Marítimo | - | Dila Gori | 1:0 (0:0) | ||
| 2nd (2nd leg) | Dila Gori | - | CS Marítimo | 0:2 (0:1) | ||
| 1st(1st leg): 23/08/2012 20:00 | 2nd (2nd leg): 30/08/2012 17:00 | Winner: CS Marítimo | ||||