| 18/02/2022 | 21:00 | O'Higgins | - | Huachipato | 1:1 (1:1) | |
| 23:30 | Unión Española | - | Everton | 1:1 (1:1) | ||
| 19/02/2022 | 21:00 | Colo-Colo | - | Audax Italiano | 1:1 (1:0) | |
| 23:30 | Antofagasta | - | La Serena | 2:2 (1:1) | ||
| 20/02/2022 | 15:00 | Coquimbo Unido | - | Palestino | 2:2 (0:2) | |
| 21:00 | Unión La Calera | - | Cobresal | 0:2 (0:0) | ||
| 23:30 | Universidad Católica | - | Curicó Unido | 1:0 (0:0) | ||
| 21/02/2022 | 21:00 | Ñublense | - | Universidad de Chile | 3:2 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Universidad Católica | 3 | 3 | 0 | 0 | 6:3 | 3 | 9 |
| 2 |
|
Ñublense | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 3 |
|
Curicó Unido | 3 | 2 | 0 | 1 | 7:3 | 4 | 6 |
| 4 |
|
Universidad de Chile | 3 | 2 | 0 | 1 | 8:6 | 2 | 6 |
| 5 |
|
Cobresal | 3 | 2 | 0 | 1 | 5:3 | 2 | 6 |
| 6 |
|
Colo-Colo | 3 | 1 | 2 | 0 | 4:2 | 2 | 5 |
| 7 |
|
Palestino | 3 | 1 | 2 | 0 | 4:3 | 1 | 5 |
| 8 |
|
O'Higgins | 3 | 1 | 1 | 1 | 4:2 | 2 | 4 |
| 9 |
|
Everton | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
| 10 |
|
Huachipato | 3 | 1 | 1 | 1 | 3:6 | -3 | 4 |
| 11 |
|
Unión Española | 3 | 0 | 2 | 1 | 3:4 | -1 | 2 |
| 12 |
|
La Serena | 3 | 0 | 2 | 1 | 3:6 | -3 | 2 |
| 13 |
|
Antofagasta | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 |
|
|
Audax Italiano | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 | |
| 15 |
|
Coquimbo Unido | 3 | 0 | 1 | 2 | 4:7 | -3 | 1 |
| 16 |
|
Unión La Calera | 3 | 0 | 1 | 2 | 2:6 | -4 | 1 |
| Copa Libertadores | |
| Qualification | |
| Copa Sudamericana | |
| Relegation |