| 14/08/2021 | 00:00 | Audax Italiano | - | Santiago Wanderers | 1:0 (0:0) | |
| 16:30 | Antofagasta | - | O'Higgins | 2:1 (2:0) | ||
| 19:00 | La Serena | - | Unión La Calera | 1:2 (0:1) | ||
| 21:30 | Unión Española | - | Colo-Colo | 0:1 (0:0) | ||
| 15/08/2021 | 00:00 | Everton | - | Deportes Melipilla | 1:2 (1:2) | |
| 19:00 | Palestino | - | Curicó Unido | 0:2 (0:0) | ||
| 21:30 | Universidad de Chile | - | Cobresal | 0:2 (0:1) | ||
| 16/08/2021 | 00:00 | Huachipato | - | Universidad Católica | 2:1 (2:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Unión La Calera | 15 | 9 | 4 | 2 | 17:12 | 5 | 31 |
| 2 |
|
Colo-Colo | 15 | 9 | 3 | 3 | 24:13 | 11 | 30 |
| 3 |
|
Audax Italiano | 15 | 7 | 6 | 2 | 16:11 | 5 | 27 |
| 4 |
|
Universidad Católica | 15 | 8 | 1 | 6 | 24:19 | 5 | 25 |
| 5 |
|
Universidad de Chile | 15 | 7 | 4 | 4 | 17:13 | 4 | 25 |
| 6 |
|
Antofagasta | 15 | 6 | 5 | 4 | 20:17 | 3 | 23 |
| 7 |
|
Everton | 15 | 6 | 5 | 4 | 15:13 | 2 | 23 |
| 8 |
|
Unión Española | 15 | 6 | 3 | 6 | 23:21 | 2 | 21 |
| 9 |
|
La Serena | 15 | 5 | 5 | 5 | 22:17 | 5 | 20 |
| 10 |
|
Ñublense | 15 | 5 | 5 | 5 | 20:16 | 4 | 20 |
| 11 |
|
Cobresal | 15 | 5 | 4 | 6 | 17:17 | 0 | 19 |
| 12 |
|
Deportes Melipilla | 15 | 5 | 4 | 6 | 21:23 | -2 | 19 |
| 13 |
|
O'Higgins | 16 | 4 | 7 | 5 | 13:20 | -7 | 19 |
| 14 |
|
Palestino | 15 | 5 | 2 | 8 | 19:24 | -5 | 17 |
| 15 |
|
Huachipato | 15 | 3 | 7 | 5 | 18:20 | -2 | 16 |
| 16 |
|
Curicó Unido | 15 | 3 | 4 | 8 | 15:22 | -7 | 13 |
| 17 |
|
Santiago Wanderers | 15 | 0 | 1 | 14 | 6:29 | -23 | 1 |
| Copa Libertadores | |
| Qualification | |
| Copa Sudamericana | |
| Playoffs | |
| Relegation |