| 11/04/2022 | 17:00 | Sporting Charleroi II | - | KV Mechelen II | 0:4 | |
| 18:30 | Sint-Truidense VV II | - | Standard Liège II | 2:3 | ||
| 18:30 | Royal Antwerp FC II | - | Cercle Brugge II | 1:1 | ||
| 18:30 | RSC Anderlecht II | - | Oud-Heverlee Leuven II | 2:0 | ||
| 18:30 | Club NXT | - | KAA Gent II | 2:0 | ||
| 18:30 | SV Zulte Waregem II | - | KRC Genk II | 1:3 |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk II | 21 | 18 | 3 | 0 | 65:20 | 45 | 57 |
| 2 |
|
RSC Anderlecht II | 21 | 15 | 2 | 4 | 49:16 | 33 | 47 |
| 3 |
|
Club NXT | 21 | 12 | 4 | 5 | 46:13 | 33 | 40 |
| 4 |
|
Standard Liège II | 21 | 12 | 4 | 5 | 35:27 | 8 | 40 |
| 5 |
|
KAA Gent II | 21 | 11 | 4 | 6 | 37:29 | 8 | 37 |
| 6 |
|
Sint-Truidense VV II | 21 | 6 | 4 | 11 | 25:38 | -13 | 22 |
| 7 |
|
Sporting Charleroi II | 21 | 6 | 3 | 12 | 19:45 | -26 | 21 |
| 8 |
|
Oud-Heverlee Leuven II | 21 | 6 | 2 | 13 | 25:37 | -12 | 20 |
| 9 |
|
Royal Antwerp FC II | 21 | 5 | 5 | 11 | 26:41 | -15 | 20 |
| 10 |
|
Cercle Brugge II | 21 | 4 | 6 | 11 | 25:35 | -10 | 18 |
| 11 |
|
SV Zulte Waregem II | 21 | 5 | 3 | 13 | 28:50 | -22 | 18 |
| 12 |
|
KV Mechelen II | 21 | 4 | 4 | 13 | 18:47 | -29 | 16 |
| Relegation |