| 1st(1st leg) | Avenir Beggen | - | PSV Eindhoven | 0:2 (0:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Avenir Beggen | 4:0 (3:0) | ||
| 1st(1st leg): 11/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | Valur Reykjavík | - | FC Nantes | 2:1 (0:0) | ||
| 2nd (2nd leg) | FC Nantes | - | Valur Reykjavík | 3:0 (1:0) | ||
| 1st(1st leg): 17/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: FC Nantes | ||||
| 1st(1st leg) | SK Slavia Praha IPS | - | St. Mirren FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | St. Mirren FC | - | SK Slavia Praha IPS | 3:0 (1:0, 1:0) aet | ||
| 1st(1st leg): 17/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: St. Mirren FC | ||||
| 1st(1st leg) | AEK Athen | - | Real Madrid | 1:0 (1:0) | ||
| 2nd (2nd leg) | Real Madrid | - | AEK Athen | 5:0 (4:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Real Madrid | ||||
| 1st(1st leg) | Chernomorets Odessa | - | Werder Bremen | 2:1 (2:0) | ||
| 2nd (2nd leg) | Werder Bremen | - | Chernomorets Odessa | 3:2 (1:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Chernomorets Odessa | ||||
| 1st(1st leg) | Sparta Rotterdam | - | Hamburger SV | 2:0 (0:0) | ||
| 2nd (2nd leg) | Hamburger SV | - | Sparta Rotterdam | 3:4 (0:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Sparta Rotterdam | ||||
| 1st(1st leg) | Bor. Mönchengladbach | - | Lech Poznań | 1:1 (0:0) | ||
| 2nd (2nd leg) | Lech Poznań | - | Bor. Mönchengladbach | 0:2 (0:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Bor. Mönchengladbach | ||||
| 1st(1st leg) | Bohemian FC | - | Dundee United | 2:5 (1:3) | ||
| 2nd (2nd leg) | Dundee United | - | Bohemian FC | 2:2 (2:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Dundee United | ||||
| 1st(1st leg) | Dinamo Bucureşti | - | Vardar Skopje | 2:1 (1:1) | ||
| 2nd (2nd leg) | Vardar Skopje | - | Dinamo Bucureşti | 1:0 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Vardar Skopje | ||||
| 1st(1st leg) | APOEL Nikosia | - | Lokomotiv Sofia | 2:2 (1:1) | ||
| 2nd (2nd leg) | Lokomotiv Sofia | - | APOEL Nikosia | 4:2 (1:2, 2:2) aet | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Lokomotiv Sofia | ||||
| 1st(1st leg) | Neuchâtel Xamax FC | - | Sportul Studenţesc | 3:0 (2:0) | ||
| 2nd (2nd leg) | Sportul Studenţesc | - | Neuchâtel Xamax FC | 4:4 (4:2) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 03/10/1985 | Winner: Neuchâtel Xamax FC | ||||
| 1st(1st leg) | Portimonense SC | - | Partizan | 1:0 (0:0) | ||
| 2nd (2nd leg) | Partizan | - | Portimonense SC | 4:0 (2:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Partizan | ||||
| 1st(1st leg) | Spartak Moskva | - | TPS Turku | 1:0 (1:0) | ||
| 2nd (2nd leg) | TPS Turku | - | Spartak Moskva | 1:3 (1:2) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Spartak Moskva | ||||
| 1st(1st leg) | Legia Warszawa | - | Viking FK | 3:0 (1:0) | ||
| 2nd (2nd leg) | Viking FK | - | Legia Warszawa | 1:1 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Legia Warszawa | ||||
| 1st(1st leg) | Videoton SC | - | Malmö FF | 1:0 (0:0) | ||
| 2nd (2nd leg) | Malmö FF | - | Videoton SC | 3:2 (0:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Videoton SC | ||||
| 1st(1st leg) | Linzer ASK | - | TJ Baník Ostrava OKD | 2:0 (1:0) | ||
| 2nd (2nd leg) | TJ Baník Ostrava OKD | - | Linzer ASK | 0:1 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 01/10/1985 | Winner: Linzer ASK | ||||
| 1st(1st leg) | Inter | - | FC St. Gallen | 5:1 (3:0) | ||
| 2nd (2nd leg) | FC St. Gallen | - | Inter | 0:0 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Inter | ||||
| 1st(1st leg) | KSV Waregem | - | Aarhus GF | 5:2 (1:1) | ||
| 2nd (2nd leg) | Aarhus GF | - | KSV Waregem | 0:1 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: KSV Waregem | ||||
| 1st(1st leg) | Rangers FC | - | CA Osasuna | 1:0 (0:0) | ||
| 2nd (2nd leg) | CA Osasuna | - | Rangers FC | 2:0 (2:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: CA Osasuna | ||||
| 1st(1st leg) | Coleraine FC | - | 1. FC Lokomotive Leipzig | 1:1 (1:0) | ||
| 2nd (2nd leg) | 1. FC Lokomotive Leipzig | - | Coleraine FC | 5:0 (4:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: 1. FC Lokomotive Leipzig | ||||
| 1st(1st leg) | AJ Auxerre | - | AC Milan | 3:1 (1:1) | ||
| 2nd (2nd leg) | AC Milan | - | AJ Auxerre | 3:0 (2:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: AC Milan | ||||
| 1st(1st leg) | BSG Wismut Aue | - | Dnepr Dnepropetrovsk | 1:3 (0:1) | ||
| 2nd (2nd leg) | Dnepr Dnepropetrovsk | - | BSG Wismut Aue | 2:1 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Dnepr Dnepropetrovsk | ||||
| 1st(1st leg) | Torino FC | - | Panathinaikos | 2:1 (0:0) | ||
| 2nd (2nd leg) | Panathinaikos | - | Torino FC | 1:1 (0:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Torino FC | ||||
| 1st(1st leg) | Hajduk Split | - | FC Metz | 5:1 (2:1) | ||
| 2nd (2nd leg) | FC Metz | - | Hajduk Split | 2:2 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Hajduk Split | ||||
| 1st(1st leg) | Sporting CP | - | Feyenoord | 3:1 (2:0) | ||
| 2nd (2nd leg) | Feyenoord | - | Sporting CP | 2:1 (1:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 01/10/1985 | Winner: Sporting CP | ||||
| 1st(1st leg) | Dinamo Tiranë | - | Hamrun Spartans | 1:0 (0:0) | ||
| 2nd (2nd leg) | Hamrun Spartans | - | Dinamo Tiranë | 0:0 (0:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Dinamo Tiranë | ||||
| 1st(1st leg) | RFC Liège | - | SSW Innsbruck | 1:0 (0:0) | ||
| 2nd (2nd leg) | SSW Innsbruck | - | RFC Liège | 1:3 (1:2) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: RFC Liège | ||||
| 1st(1st leg) | Athletic Club | - | Beşiktaş | 4:1 (1:1) | ||
| 2nd (2nd leg) | Beşiktaş | - | Athletic Club | 0:1 (0:1) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 03/10/1985 | Winner: Athletic Club | ||||
| 1st(1st leg) | FC Pirin | - | Hammarby IF | 1:3 (1:1) | ||
| 2nd (2nd leg) | Hammarby IF | - | FC Pirin | 4:0 (1:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Hammarby IF | ||||
| 1st(1st leg) | Győri ETO FC | - | TJ Bohemians ČKD Praha | 3:1 (1:1) | ||
| 2nd (2nd leg) | TJ Bohemians ČKD Praha | - | Győri ETO FC | 4:1 (2:1, 3:1) aet | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: TJ Bohemians ČKD Praha | ||||
| 1st(1st leg) | 1. FC Köln | - | Sporting Gijón | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sporting Gijón | - | 1. FC Köln | 1:2 (1:0) | ||
| 1st(1st leg): 18/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | Boavista | - | Club Brugge KV | 4:3 (1:1) | ||
| 2nd (2nd leg) | Club Brugge KV | - | Boavista | 3:1 (1:1) | ||
| 1st(1st leg): 19/09/1985 | 2nd (2nd leg): 02/10/1985 | Winner: Club Brugge KV | ||||