| 29/03/2021 | 00:00 | Boston River | - | Liverpool | 1:0 (0:0) | |
| 00:00 | Deportivo Maldonado | - | Nacional | 1:2 (0:1) | ||
| 00:00 | Rentistas | - | Danubio | 1:0 (0:0) | ||
| 00:00 | Cerro Largo | - | Defensor Sporting | 0:0 (0:0) | ||
| 14:00 | Montevideo Wanderers | - | CA Cerro | 1:1 (1:0) | ||
| 20:00 | River Plate | - | Progreso | 3:2 (2:0) | ||
| 22:15 | Montevideo City Torque | - | Plaza Colonia | 2:0 (1:0) | ||
| 30/03/2021 | 01:15 | Peñarol | - | Fénix | 3:1 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Liverpool | 15 | 10 | 4 | 1 | 34:13 | 21 | 34 |
| 2 |
|
Peñarol | 15 | 8 | 5 | 2 | 20:12 | 8 | 29 |
| 3 |
|
Montevideo City Torque | 15 | 7 | 5 | 3 | 30:14 | 16 | 26 |
| 4 |
|
Nacional | 15 | 7 | 5 | 3 | 19:16 | 3 | 26 |
| 5 |
|
Plaza Colonia | 15 | 7 | 4 | 4 | 28:16 | 12 | 25 |
| 6 |
|
Boston River | 15 | 7 | 1 | 7 | 23:26 | -3 | 22 |
| 7 |
|
River Plate | 15 | 6 | 3 | 6 | 21:22 | -1 | 21 |
| 8 |
|
Fénix | 15 | 5 | 6 | 4 | 24:26 | -2 | 21 |
| 9 |
|
Montevideo Wanderers | 15 | 4 | 6 | 5 | 24:28 | -4 | 18 |
| 10 |
|
Deportivo Maldonado | 15 | 4 | 6 | 5 | 21:27 | -6 | 18 |
| 11 |
|
Cerro Largo | 15 | 4 | 4 | 7 | 15:17 | -2 | 16 |
| 12 |
|
Danubio | 15 | 4 | 3 | 8 | 17:23 | -6 | 15 |
| 13 |
|
Progreso | 15 | 4 | 3 | 8 | 14:24 | -10 | 15 |
| 14 |
|
CA Cerro | 15 | 3 | 5 | 7 | 16:21 | -5 | 14 |
| 15 |
|
Defensor Sporting | 15 | 2 | 8 | 5 | 15:21 | -6 | 14 |
| 16 |
|
Rentistas | 15 | 2 | 4 | 9 | 12:27 | -15 | 10 |
| Playoffs |