| 27/08/2021 | 19:00 | Fortuna Sittard | - | RKC Waalwijk | 2:2 (1:1) | |
| 28/08/2021 | 17:45 | SC Cambuur | - | FC Twente | 2:0 (0:0) | |
| 19:00 | Go Ahead Eagles | - | Sparta Rotterdam | 2:0 (1:0) | ||
| 19:00 | PSV Eindhoven | - | FC Groningen | 5:2 (3:2) | ||
| 20:00 | Willem II | - | PEC Zwolle | 1:0 (0:0) | ||
| 29/08/2021 | 11:15 | FC Utrecht | - | Feyenoord | 3:1 (1:1) | |
| 13:30 | AFC Ajax | - | Vitesse | 5:0 (3:0) | ||
| 13:30 | Heracles Almelo | - | NEC Nijmegen | 0:1 (0:0) | ||
| 15:45 | sc Heerenveen | - | AZ Alkmaar | 1:3 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PSV Eindhoven | 3 | 3 | 0 | 0 | 11:3 | 8 | 9 |
| 2 |
|
AFC Ajax | 3 | 2 | 1 | 0 | 11:1 | 10 | 7 |
| 3 |
|
FC Utrecht | 3 | 2 | 1 | 0 | 7:1 | 6 | 7 |
| 4 |
|
Feyenoord | 3 | 2 | 0 | 1 | 7:3 | 4 | 6 |
| 5 |
|
AZ Alkmaar | 3 | 2 | 0 | 1 | 5:3 | 2 | 6 |
| 6 |
|
sc Heerenveen | 3 | 2 | 0 | 1 | 5:5 | 0 | 6 |
| 7 |
|
Willem II | 3 | 2 | 0 | 1 | 4:4 | 0 | 6 |
| 8 |
|
NEC Nijmegen | 3 | 2 | 0 | 1 | 3:5 | -2 | 6 |
| 9 |
|
Fortuna Sittard | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
|
|
RKC Waalwijk | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 | |
| 11 |
|
FC Groningen | 3 | 1 | 1 | 1 | 4:6 | -2 | 4 |
| 12 |
|
Go Ahead Eagles | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 13 |
|
SC Cambuur | 3 | 1 | 0 | 2 | 4:6 | -2 | 3 |
| 14 |
|
Vitesse | 3 | 1 | 0 | 2 | 1:8 | -7 | 3 |
| 15 |
|
FC Twente | 3 | 0 | 1 | 2 | 2:5 | -3 | 1 |
| 16 |
|
Heracles Almelo | 3 | 0 | 1 | 2 | 1:4 | -3 | 1 |
| 17 |
|
Sparta Rotterdam | 3 | 0 | 1 | 2 | 1:7 | -6 | 1 |
| 18 |
|
PEC Zwolle | 3 | 0 | 0 | 3 | 0:4 | -4 | 0 |
| Champions League | |
| Champions League Quali. | |
| Europa League Quali. | |
| Playoffs | |
| Playoffs | |
| Relegation |