| 1. Round | 06/08/2021 | AS Monaco | - | FC Nantes | 1:1 | ||||
| 2. Round | 15/08/2021 | FC Nantes | - | FC Metz | 2:0 | ||||
| 3. Round | 22/08/2021 | Stade Rennais | - | FC Nantes | 1:0 | ||||
| 4. Round | 27/08/2021 | FC Nantes | - | Olympique Lyonnais | 0:1 | ||||
| 10. Round | 17/10/2021 | Girondins Bordeaux | - | FC Nantes | 1:1 | ||||
| 11. Round | 23/10/2021 | FC Nantes | - | Clermont Foot 63 | 2:1 | ||||
| 12. Round | 31/10/2021 | Montpellier HSC | - | FC Nantes | 2:0 | ||||
| 19. Round | 22/12/2021 | AS Saint-Étienne | - | FC Nantes | 0:1 | ||||
| 20. Round | 09/01/2022 | FC Nantes | - | AS Monaco | 0:0 | ||||
| 21. Round | 14/01/2022 | OGC Nice | - | FC Nantes | 2:1 | ||||
| 22. Round | 23/01/2022 | FC Nantes | - | FC Lorient | 4:2 | ||||
| 23. Round | 06/02/2022 | RC Strasbourg | - | FC Nantes | 1:0 | ||||
| 25. Round | 19/02/2022 | FC Nantes | - | Paris Saint-Germain | 3:1 | ||||
| 26. Round | 27/02/2022 | FC Metz | - | FC Nantes | 0:0 | ||||
| 27. Round | 06/03/2022 | FC Nantes | - | Montpellier HSC | 2:0 | ||||
| 30. Round | 03/04/2022 | Clermont Foot 63 | - | FC Nantes | 2:3 | ||||
| 35. Round | 30/04/2022 | RC Lens | - | FC Nantes | 2:2 |