AmiGO 2: Term Details for "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels" (GO:0099635)

Term Information

Accession: GO:0099635
Name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission. Source: GOC:dos
Comment: None
History: See term history for GO:0099635 at QuickGO
Chem. react.: None
Subset: goslim_synapse
Related: Link to all genes and gene products annotated to voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels (excluding "regulates").; Link to all direct and indirect annotations to voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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Total annotations: 1

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	Gene/product	Gene/product name	Annotation qualifier	GO class (direct)	Annotation extension	Contributor	Organism	Evidence	Evidence with	PANTHER family	Type	Isoform	Reference	Date
	Cacna1d	Voltage-dependent L-type calcium channel subunit alpha-1D		voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels		Reactome	Mus musculus	TAS		voltage-dependent calcium channel type a subunit alpha-1 pthr45628	protein		Reactome:R-MMU-9659489	20240514

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UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0051179 localization
GO:0003674 molecular_function
GO:0050789 regulation of biological process
GO:0006810 transport
CARO:0030000 biological entity
GO:0065007 biological regulation
GO:0008150 biological_process
GO:0007154 cell communication
GO:0051234 establishment of localization
GO:0006811 monoatomic ion transport
UBERON:0010000 multicellular anatomical structure
GO:0050794 regulation of cellular process
GO:0032879 regulation of localization
GO:0051049 regulation of transport
GO:0046903 secretion
GO:0023052 signaling
GO:0055085 transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0005215 transporter activity
GO:0016192 vesicle-mediated transport
CARO:0000000 anatomical entity
GO:0007267 cell-cell signaling
GO:0015267 channel activity
GO:0006887 exocytosis
GO:0140352 export from cell
GO:0098660 inorganic ion transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0030001 metal ion transport
GO:0006812 monoatomic cation transport
GO:0034220 monoatomic ion transmembrane transport
UBERON:0000468 multicellular organism
GO:0032501 multicellular organismal process
GO:0006836 neurotransmitter transport
GO:0022803 passive transmembrane transporter activity
GO:0048518 positive regulation of biological process
GO:0048522 positive regulation of cellular process
GO:0051050 positive regulation of transport
GO:0010646 regulation of cell communication
GO:0051046 regulation of secretion
GO:1903530 regulation of secretion by cell
GO:0023051 regulation of signaling
GO:0060627 regulation of vesicle-mediated transport
GO:0032940 secretion by cell
GO:0045202 synapse
UBERON:0001062 anatomical entity
UBERON:0000467 anatomical system
GO:0006816 calcium ion transport
CL:0000000 cell
GO:0051641 cellular localization
GO:0007268 chemical synaptic transmission
GO:0051649 establishment of localization in cell
GO:0022836 gated channel activity
GO:0098662 inorganic cation transmembrane transport
GO:0022890 inorganic cation transmembrane transporter activity
CARO:0000006 material anatomical entity
GO:0050804 modulation of chemical synaptic transmission
GO:0098655 monoatomic cation transmembrane transport
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0050877 nervous system process
GO:0007269 neurotransmitter secretion
GO:0010647 positive regulation of cell communication
GO:0051047 positive regulation of secretion
GO:1903532 positive regulation of secretion by cell
GO:0023056 positive regulation of signaling
GO:0098793 presynapse
GO:0045055 regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0051588 regulation of neurotransmitter transport
GO:0023061 signal release
GO:0099643 signal release from synapse
GO:0099536 synaptic signaling
GO:0003008 system process
GO:0099537 trans-synaptic signaling
GO:0099003 vesicle-mediated transport in synapse
GO:0070588 calcium ion transmembrane transport
GO:0110165 cellular anatomical structure
CARO:0000003 connected anatomical structure
CL:0000211 electrically active cell
CL:0000255 eukaryotic cell
UBERON:0000465 material anatomical entity
GO:0046873 metal ion transmembrane transporter activity
GO:0005216 monoatomic ion channel activity
UBERON:0001016 nervous system
GO:0045921 positive regulation of exocytosis
GO:0051590 positive regulation of neurotransmitter transport
GO:0050806 positive regulation of synaptic transmission
GO:0065008 regulation of biological quality
GO:0046928 regulation of neurotransmitter secretion
GO:1903305 regulation of regulated secretory pathway
GO:0099177 regulation of trans-synaptic signaling
GO:0099504 synaptic vesicle cycle
GO:0016079 synaptic vesicle exocytosis
GO:0022832 voltage-gated channel activity
GO:0098916 anterograde trans-synaptic signaling
GO:0015085 calcium ion transmembrane transporter activity
GO:0030054 cell junction
GO:0005575 cellular_component
CL:0000393 electrically responsive cell
CL:0000404 electrically signaling cell
GO:0005261 monoatomic cation channel activity
CL:0002319 neural cell
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0001956 positive regulation of neurotransmitter secretion
GO:1903307 positive regulation of regulated secretory pathway
GO:2000300 regulation of synaptic vesicle exocytosis
GO:0019226 transmission of nerve impulse
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005262 calcium channel activity
CL:0000540 neuron
GO:0099533 positive regulation of presynaptic cytosolic calcium concentration
GO:2000302 positive regulation of synaptic vesicle exocytosis
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0099703 induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
GO:0005245 voltage-gated calcium channel activity
GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

Parents of voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels (GO:0099635)

subject	relation	object
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	is_a	voltage-gated calcium channel activity (GO:0005245)
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	BFO:0000050	induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration (GO:0099703)
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	BFO:0000066	presynapse (GO:0098793)
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	RO:0002162	Metazoa (NCBITaxon:33208)
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	BFO:0000050	positive regulation of presynaptic cytosolic calcium concentration (GO:0099533)

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Reactome: R-HSA-9659515