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signal transduction

Term Information

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Accession
GO:0007165
Name
signal transduction
Ontology
biological_process
Synonyms
signaling pathway, signalling pathway, signaling cascade, signalling cascade
Alternate IDs
GO:0023016, GO:0023014, GO:0023015, GO:0023045, GO:0023033
Definition
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Source: GOC:mtg_signaling_feb11, GOC:go_curators
Comment
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
History
See term history for GO:0007165 at QuickGO
Chem. react.
None
Subset
goslim_metagenomics
goslim_chembl
goslim_plant
goslim_plant_ribbon
goslim_candida
Link to all genes and gene products annotated to signal transduction (excluding "regulates").
Link to all direct and indirect annotations to signal transduction (excluding "regulates").
Link to all direct and indirect annotations download (limited to first 10,000) for signal transduction (excluding "regulates").
Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

Total annotations: 298759
User filters
+isa_partof_closure: GO:0007165
Your search is pinned to these filters
−document_category: annotation

Ontology (aspect)

(215890)P
(82869)F

Organism

(295230)Eukaryota
(245222)Metazoa
(217379)Vertebrata
(153034)Mammalia
(36177)Viridiplantae
(24583)Homo sapiens
(23084)Rattus norvegicus
(21927)Mus musculus
(21604)Sus scrofa
(18805)Bos taurus
(16499)Canis lupus familiaris
(14288)Danio rerio
(13659)Gallus gallus
(12620)Xenopus tropicalis
(12364)Xenopus laevis
(8205)Fungi
(4751)Drosophila melanogaster
(4537)Caenorhabditis elegans
(4148)Oryzias latipes
(3781)Pan troglodytes
(3673)Macaca mulatta
(3671)Equus caballus
(3539)Felis catus
(3437)Monodelphis domestica

Type

(249904)protein
(27690)gene
(15341)protein_coding_gene
(4862)gene_product
(689)protein_complex
(125)mRNA
(40)miRNA_gene
(30)miRNA
(25)pseudogene
(21)gene_segment
(16)pre_miRNA
(10)lncRNA_gene
(3)antisense_lncRNA_gene
(2)biological region
(1)ncRNA

Evidence

(162110)similarity evidence used in manual assertion
(139225)biological aspect of ancestor evidence used in manual assertion
(110589)evidence used in automatic assertion
(21064)experimental evidence
(11878)sequence orthology evidence used in manual assertion
(10094)direct assay evidence used in manual assertion
(9598)sequence similarity evidence used in manual assertion
(7389)mutant phenotype evidence used in manual assertion
(3297)author statement supported by traceable reference used in manual assertion
(2696)genetic interaction evidence used in manual assertion
(1400)author statement without traceable support used in manual assertion
(1198)sequence alignment evidence used in manual assertion
(428)physical interaction evidence used in manual assertion
(248)curator inference used in manual assertion
(205)match to sequence model evidence used in manual assertion
(174)expression pattern evidence used in manual assertion
(170)high throughput expression pattern evidence used in manual assertion
(101)experimental evidence used in manual assertion
(51)automatically integrated combinatorial evidence used in manual assertion
(6)high throughput mutant phenotypic evidence used in manual assertion
(6)phylogenetic determination of loss of key residues evidence used in manual assertion
(4)high throughput genetic interaction phenotypic evidence used in manual assertion
(2)high throughput direct assay evidence used in manual assertion

GO class (including "regulates")

The top (10) redundant fields are not shown
(91010)G protein-coupled receptor signaling pathway
(82932)molecular_function
(77415)anatomical entity
(77415)anatomical structure
(77415)biological entity
(77415)connected anatomical structure
(77415)material anatomical entity
(76212)cell
(75995)molecular transducer activity
(75188)cellular anatomical structure
(75188)cellular_component
(75174)signaling receptor activity
(74773)cell surface receptor signaling pathway
(67914)intracellular anatomical structure

GO class (excluding "regulates")

The top (10) redundant fields are not shown
(91010)G protein-coupled receptor signaling pathway
(82869)molecular_function
(74773)cell surface receptor signaling pathway
(67786)intracellular signal transduction
(58902)molecular transducer activity
(58081)signaling receptor activity
(51751)transmembrane signaling receptor activity
(40114)G protein-coupled receptor activity
(30797)response to chemical
(24106)enzyme-linked receptor protein signaling pathway
(23623)intracellular signaling cassette
(19426)response to endogenous stimulus
(19403)cellular response to endogenous stimulus
(18297)cellular response to chemical stimulus

GO class (direct)

(39830)signal transduction
(32583)G protein-coupled receptor signaling pathway
(25845)G protein-coupled receptor activity
(15003)intracellular signal transduction
(5651)cell surface receptor signaling pathway
(4962)cytokine activity
(4129)adenylate cyclase-activating G protein-coupled receptor signaling pathway
(3873)growth factor activity
(2889)hormone activity
(2882)cell surface receptor protein tyrosine kinase signaling pathway
(2863)neuropeptide signaling pathway
(2650)canonical Wnt signaling pathway
(2570)Wnt signaling pathway
(2506)MAPK cascade
(2493)small GTPase-mediated signal transduction
(2406)endoplasmic reticulum unfolded protein response
(2382)hormone-mediated signaling pathway
(2353)Notch signaling pathway
(2342)nuclear receptor activity
(2218)cytokine-mediated signaling pathway
(2198)calcium-mediated signaling
(1968)Ras protein signal transduction
(1881)integrin-mediated signaling pathway
(1720)BMP signaling pathway

Annotation qualifier

(798)contributes_to
(251)not

Annotation extension

(2438)anatomical entity
(2438)anatomical structure
(2438)biological entity
(2438)connected anatomical structure
(2438)material anatomical entity
(2094)biological_process
(1975)cell
(1936)eukaryotic cell
(1664)multicellular anatomical structure
(1655)multicellular organism
(1358)anatomical system
(1305)cellular process
(1176)biological regulation
(1143)regulation of biological process
(1077)response to stimulus
(1075)disconnected anatomical group
(1056)regulation of cellular process
(988)tissue
(900)cellular response to stimulus
(887)non-connected functional system
(842)organ
(829)nervous system
(758)cell communication
(754)signaling

Contributor

(143369)GO_Central
(48964)UniProt
(32521)InterPro
(22608)Ensembl
(9789)RGD
(9310)ZFIN
(6801)MGI
(5868)GOC
(4353)CGD
(3127)FlyBase
(2118)BHF-UCL
(1594)PINC
(1536)AgBase
(1006)ComplexPortal
(973)TAIR
(722)WB
(568)SGD
(458)ARUK-UCL
(448)PomBase
(352)Reactome
(302)dictyBase
(281)ParkinsonsUK-UCL
(261)HGNC-UCL
(237)SGN

PANTHER family

(6538)tyrosine-protein kinase receptor pthr24416
(4966)olfactory receptor pthr26453
(4438)5-hydroxytryptamine receptor pthr24247
(4082)neurotransmitter gated ion channel pthr18945
(3922)olfactory receptor pthr48001
(3779)olfactory receptor pthr26452
(3399)adrenergic receptor-related g-protein coupled receptor pthr24248
(3357)olfactory receptor pthr48018
(3335)mitogen-activated protein kinase pthr24055
(3334)opsin pthr24240
(2957)serine/threonine-protein kinase tnni3k-related pthr44329
(2949)olfactory receptor 56b1-related pthr26450
(2802)receptor-like serine/threonine-protein kinase sd1-8 pthr27002
(2777)tgf-beta family pthr11848
(2582)pdf receptor-like protein-related pthr45620
(2573)cell adhesion molecule pthr10489
(2534)neuropeptide receptor-related g-protein coupled receptor pthr24241
(2512)serine/threonine-protein kinase pthr24349
(2497)olfactory receptor pthr48002
(2423)g-protein coupled receptor pthr22750
(2260)ionotropic glutamate receptor pthr18966
(2252)serine/threonine-protein kinase pthr24356
(2222)wall-associated receptor kinase-like 21 pthr27005
(2198)gtp-binding protein alpha subunit pthr10218
Total annotations: 298759; showing: 1-10
Results count  
 
Gene/productGene/product nameAnnotation qualifierGO class (direct)Annotation extensionContributorOrganismEvidenceEvidence withPANTHER familyTypeIsoformReferenceDate
20197715protein-serine_threonine phosphatasecalcineurin-mediated signalingGO_CentralHelobdella robustaIBAPANTHER:PTN000746105
PomBase:SPBP4H10.04 		serine/threonine-protein phosphatase 2b catalytic subunit 1-related pthr45673proteinGO_REF:000003320201001
20197701Uncharacterized proteinsignal transductionGO_CentralHelobdella robustaIBAPANTHER:PTN000632671
UniProtKB:Q8IXI1 		rho family gtpase pthr24072proteinGO_REF:000003320241120
grb10Growth factor receptor bound protein 10insulin receptor signaling pathwayGO_CentralOryzias latipesIBAPANTHER:PTN000133510
RGD:61869
RGD:1566234		growth factor receptor-bound protein pthr11243proteinGO_REF:000003320190207
melkMaternal embryonic leucine zipper kinaseintracellular signal transductionGO_CentralOryzias latipesIBAPANTHER:PTN002519176
UniProtKB:Q7KZI7 		map/microtubule affinity-regulating kinase pthr24346proteinGO_REF:000003320240919
LOC101172489Disintegrin and metalloproteinase domain-containing protein 10Notch signaling pathwayGO_CentralOryzias latipesIBAPANTHER:PTN001374824
FB:FBgn0039734 		adam10/adam17 metallopeptidase family member pthr45702proteinGO_REF:000003320240229
garem1GRB2 associated regulator of MAPK1 subtype 1epidermal growth factor receptor signaling pathwayGO_CentralOryzias latipesIBAPANTHER:PTN002683723
UniProtKB:Q9H706		grb2-associated and regulator of mapk protein family member pthr14454proteinGO_REF:000003320190321
100279494Ubiquitin thioesterase OTUendoplasmic reticulum unfolded protein responseGO_CentralZea maysIBAPANTHER:PTN000329911
UniProtKB:Q5VVQ6		hiv-induced protein-7-like protease pthr13312proteinGO_REF:000003320170228
20197599Uncharacterized proteinadenylate cyclase-modulating G protein-coupled receptor signaling pathwayGO_CentralHelobdella robustaIBAPANTHER:PTN000026392
UniProtKB:P63096 		gtp-binding protein alpha subunit pthr10218proteinGO_REF:000003320241119
20197589Cell division control protein 42 homologsignal transductionGO_CentralHelobdella robustaIBAPANTHER:PTN000632671
UniProtKB:Q8IXI1 		rho family gtpase pthr24072proteinGO_REF:000003320241120
LOC101171316receptor protein-tyrosine kinasetransmembrane-ephrin receptor activityGO_CentralOryzias latipesIBAPANTHER:PTN000699977
UniProtKB:P54762 		eph receptor a5 pthr46877proteinGO_REF:000003320241121
View this term in QuickGO.

Graph of GO:0007165 from QuickGO

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Parents of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
signal transduction [is_a relation] is_a  cellular process (GO:0009987)
signal transduction [is_a relation] is_a  regulation of cellular process (GO:0050794)
signal transduction [BFO:0000050 relation] BFO:0000050  signaling (GO:0023052)
signal transduction [BFO:0000050 relation] BFO:0000050  cellular response to stimulus (GO:0051716)
signal transduction [BFO:0000050 relation] BFO:0000050  cell communication (GO:0007154)
Children of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cell surface receptor signaling pathway (GO:0007166) [is_a relation] is_a  signal transduction
granzyme-mediated programmed cell death signaling pathway (GO:0140507) [is_a relation] is_a  signal transduction
regulation of signal transduction (GO:0009966) [RO:0002211 relation] RO:0002211  signal transduction
phototransduction (GO:0007602) [is_a relation] is_a  signal transduction
apoptotic signaling pathway (GO:0097190) [is_a relation] is_a  signal transduction
extracellular ATP signaling (GO:0106167) [is_a relation] is_a  signal transduction
symbiont-mediated activation of host signal transduction pathway (GO:0052028) [RO:0012013 relation] RO:0012013  signal transduction
necroptotic signaling pathway (GO:0097527) [is_a relation] is_a  signal transduction
presynaptic signal transduction (GO:0098928) [is_a relation] is_a  signal transduction
venom-mediated perturbation of signal transduction (GO:0044509) [RO:0002010 relation] RO:0002010  signal transduction
postsynaptic signal transduction (GO:0098926) [is_a relation] is_a  signal transduction
negative regulation of signal transduction (GO:0009968) [RO:0002212 relation] RO:0002212  signal transduction
receptor ligand activity (GO:0048018) [BFO:0000050 relation] BFO:0000050  signal transduction
opioid growth factor receptor signaling pathway (GO:0140626) [is_a relation] is_a  signal transduction
G protein-coupled receptor signaling pathway (GO:0007186) [is_a relation] is_a  signal transduction
serotonin receptor signaling pathway (GO:0007210) [is_a relation] is_a  signal transduction
carbohydrate mediated signaling (GO:0009756) [is_a relation] is_a  signal transduction
salicylic acid mediated signaling pathway (GO:0009863) [is_a relation] is_a  signal transduction
lipoprotein particle mediated signaling (GO:0055095) [is_a relation] is_a  signal transduction
signal transduction involved in filamentous growth (GO:0001402) [is_a relation] is_a  signal transduction
immune response-regulating signaling pathway (GO:0002764) [is_a relation] is_a  signal transduction
programmed cell death (GO:0012501) [RO:0002224 relation] RO:0002224  signal transduction
signal transduction involved in cellular response to ammonium ion (GO:1903831) [is_a relation] is_a  signal transduction
regulation of blood pressure by chemoreceptor signaling pathway (GO:0010850) [is_a relation] is_a  signal transduction
hormone-mediated signaling pathway (GO:0009755) [is_a relation] is_a  signal transduction
signal transduction involved in positive regulation of conjugation with cellular fusion (GO:0032005) [is_a relation] is_a  signal transduction
signal transduction in absence of ligand (GO:0038034) [is_a relation] is_a  signal transduction
red or far-red light signaling pathway (GO:0010017) [is_a relation] is_a  signal transduction
bile acid signaling pathway (GO:0038183) [is_a relation] is_a  signal transduction
hydrogen peroxide mediated signaling pathway (GO:0071588) [is_a relation] is_a  signal transduction
positive regulation of signal transduction (GO:0009967) [RO:0002213 relation] RO:0002213  signal transduction
symbiont-mediated perturbation of host signal transduction pathway (GO:0052027) [RO:0002010 relation] RO:0002010  signal transduction
neuronal signal transduction (GO:0023041) [is_a relation] is_a  signal transduction
regulation of floral organ abscission by signal transduction (GO:0060863) [is_a relation] is_a  signal transduction
intracellular signal transduction (GO:0035556) [is_a relation] is_a  signal transduction
signal transduction involved in regulation of gene expression (GO:0023019) [is_a relation] is_a  signal transduction
ligand-gated ion channel signaling pathway (GO:1990806) [is_a relation] is_a  signal transduction
symbiont-mediated suppression of host signal transduction pathway (GO:0052029) [RO:0012014 relation] RO:0012014  signal transduction
sphingolipid mediated signaling pathway (GO:0090520) [is_a relation] is_a  signal transduction
Reactome
R-HSA-212718
Wikipedia
Signal_transduction
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