| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11010905 | Molecular Genetics and Metabolism | 2018 | 9 Pages |
Abstract
BDI-II scores were significantly higher following 24â¯months of nitisinone therapy in patients that were followed up, however the majority of these patients remained in the minimal category of depression. Serum tyrosine and urinary 3-MT increased significantly following treatment with nitisinone. In contrast urinary 5-HIAA did not decrease consistently over the same period studied. Together these findings suggest nitisinone does not cause depression despite some observed effects on monoamine neurotransmitter metabolism.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Davison A.S., Harrold J.A., Hughes G., Norman B.P., Devine J., Usher J., Hughes A.T., Khedr M., Gallagher J.A., Milan A.M., Halford J.C.G., Ranganath L.R.,