| 20/03/2025 | 16:00 | Mazatlán FC | - | UANL Tigres | 0:3 (0:0) | |
| 04/04/2025 | 16:00 | Atlético San Luis | - | CF Monterrey | 1:0 | |
| 19/04/2025 | 15:00 | Cruz Azul | - | Puebla FC | -:- | |
| 21:45 | Gallos Blancos | - | Pumas UNAM | -:- | ||
| 21:45 | Club Necaxa | - | FC Juárez | -:- | ||
| 21:45 | Club León | - | Atlas Guadalajara | -:- | ||
| 20/04/2025 | 17:00 | CF Pachuca | - | CF América | -:- | |
| 21:45 | Santos Laguna | - | Deportivo Guadalajara | -:- |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 11 | 10 | 0 | 1 | 26:5 | 21 | 30 |
| 2 |
|
CF Pachuca | 11 | 8 | 2 | 1 | 31:5 | 26 | 26 |
| 3 |
|
Pumas UNAM | 10 | 7 | 2 | 1 | 20:7 | 13 | 23 |
| 4 |
|
Deportivo Guadalajara | 11 | 7 | 2 | 2 | 21:10 | 11 | 23 |
| 5 |
|
UANL Tigres | 11 | 6 | 5 | 0 | 19:9 | 10 | 23 |
| 6 |
|
CF Monterrey | 12 | 6 | 2 | 4 | 13:11 | 2 | 20 |
| 7 |
|
CF América | 11 | 4 | 5 | 2 | 16:10 | 6 | 17 |
| 8 |
|
Santos Laguna | 11 | 4 | 4 | 3 | 13:8 | 5 | 16 |
| 9 |
|
Club León | 11 | 4 | 4 | 3 | 13:10 | 3 | 16 |
| 10 |
|
Atlético San Luis | 12 | 3 | 4 | 5 | 9:12 | -3 | 13 |
| 11 |
|
Atlas Guadalajara | 10 | 3 | 3 | 4 | 9:10 | -1 | 12 |
| 12 |
|
Cruz Azul | 10 | 3 | 2 | 5 | 10:12 | -2 | 11 |
| 13 |
|
Club Tijuana | 11 | 3 | 2 | 6 | 12:17 | -5 | 11 |
| 14 |
|
Puebla FC | 10 | 2 | 2 | 6 | 10:20 | -10 | 8 |
| 15 |
|
FC Juárez | 11 | 1 | 5 | 5 | 6:22 | -16 | 8 |
| 16 |
|
Gallos Blancos | 11 | 1 | 2 | 8 | 3:18 | -15 | 5 |
| 17 |
|
Club Necaxa | 11 | 1 | 2 | 8 | 5:28 | -23 | 5 |
| 18 |
|
Mazatlán FC | 11 | 0 | 2 | 9 | 2:24 | -22 | 2 |