| 01/04/2006 | 12:45 | Birmingham City | - | Chelsea FC | 0:0 (0:0) | |
| 15:00 | Arsenal FC | - | Aston Villa | 5:0 (2:0) | ||
| 15:00 | Bolton Wanderers | - | Manchester United | 1:2 (1:1) | ||
| 15:00 | Everton FC | - | Sunderland AFC | 2:2 (2:1) | ||
| 15:00 | Fulham FC | - | Portsmouth FC | 1:3 (1:2) | ||
| 15:00 | Newcastle United | - | Tottenham Hotspur | 3:1 (3:1) | ||
| 17:15 | West Bromwich Albion | - | Liverpool FC | 0:2 (0:2) | ||
| 02/04/2006 | 15:00 | Manchester City | - | Middlesbrough FC | 0:1 (0:1) | |
| 16:00 | West Ham United | - | Charlton Athletic | 0:0 (0:0) | ||
| 03/04/2006 | 20:00 | Blackburn Rovers | - | Wigan Athletic | 1:1 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Chelsea FC | 32 | 25 | 4 | 3 | 60:19 | 41 | 79 |
| 2 |
|
Manchester United | 32 | 22 | 6 | 4 | 64:30 | 34 | 72 |
| 3 |
|
Liverpool FC | 32 | 19 | 7 | 6 | 42:21 | 21 | 64 |
| 4 |
|
Tottenham Hotspur | 32 | 15 | 10 | 7 | 46:32 | 14 | 55 |
| 5 |
|
Arsenal FC | 32 | 16 | 6 | 10 | 54:24 | 30 | 54 |
| 6 |
|
Blackburn Rovers | 32 | 16 | 5 | 11 | 43:37 | 6 | 53 |
| 7 |
|
Bolton Wanderers | 32 | 13 | 10 | 9 | 44:36 | 8 | 49 |
| 8 |
|
Wigan Athletic | 32 | 14 | 5 | 13 | 37:39 | -2 | 47 |
| 9 |
|
West Ham United | 32 | 13 | 7 | 12 | 46:46 | 0 | 46 |
| 10 |
|
Everton FC | 32 | 13 | 5 | 14 | 31:43 | -12 | 44 |
| 11 |
|
Charlton Athletic | 32 | 12 | 7 | 13 | 37:42 | -5 | 43 |
| 12 |
|
Newcastle United | 32 | 12 | 6 | 14 | 34:39 | -5 | 42 |
| 13 |
|
Middlesbrough FC | 32 | 11 | 8 | 13 | 45:53 | -8 | 41 |
| 14 |
|
Manchester City | 32 | 12 | 4 | 16 | 39:38 | 1 | 40 |
| 15 |
|
Fulham FC | 32 | 10 | 6 | 16 | 40:49 | -9 | 36 |
| 16 |
|
Aston Villa | 32 | 8 | 11 | 13 | 34:46 | -12 | 35 |
| 17 |
|
Birmingham City | 32 | 7 | 7 | 18 | 24:44 | -20 | 28 |
| 18 |
|
Portsmouth FC | 32 | 7 | 7 | 18 | 28:53 | -25 | 28 |
| 19 |
|
West Bromwich Albion | 32 | 7 | 6 | 19 | 28:49 | -21 | 27 |
| 20 |
|
Sunderland AFC | 32 | 2 | 5 | 25 | 21:57 | -36 | 11 |