| 21/04/2001 | 12:00 | Manchester United | - | Manchester City | 1:1 (0:0) | |
| 15:00 | West Ham United | - | Leeds United | 0:2 (0:1) | ||
| 15:00 | Arsenal FC | - | Everton FC | 4:1 (1:1) | ||
| 15:00 | Aston Villa | - | Southampton FC | 0:0 (0:0) | ||
| 15:00 | Bradford City | - | Derby County | 2:0 (1:0) | ||
| 15:00 | Chelsea FC | - | Charlton Athletic | 0:1 (0:1) | ||
| 15:00 | Ipswich Town | - | Coventry City | 2:0 (1:0) | ||
| 15:00 | Leicester City | - | Middlesbrough FC | 0:3 (0:1) | ||
| 17:15 | Sunderland AFC | - | Newcastle United | 1:1 (0:0) | ||
| 22/04/2001 | 15:00 | Liverpool FC | - | Tottenham Hotspur | 3:1 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Manchester United | 35 | 23 | 8 | 4 | 76:27 | 49 | 77 |
| 2 |
|
Arsenal FC | 35 | 18 | 10 | 7 | 57:33 | 24 | 64 |
| 3 |
|
Leeds United | 35 | 18 | 8 | 9 | 58:40 | 18 | 62 |
| 4 |
|
Ipswich Town | 35 | 19 | 5 | 11 | 53:38 | 15 | 62 |
| 5 |
|
Liverpool FC | 35 | 17 | 9 | 9 | 62:39 | 23 | 60 |
| 6 |
|
Chelsea FC | 35 | 15 | 10 | 10 | 64:41 | 23 | 55 |
| 7 |
|
Aston Villa | 35 | 12 | 14 | 9 | 43:38 | 5 | 50 |
| 8 |
|
Sunderland AFC | 35 | 13 | 11 | 11 | 40:37 | 3 | 50 |
| 9 |
|
Charlton Athletic | 35 | 13 | 10 | 12 | 46:49 | -3 | 49 |
| 10 |
|
Southampton FC | 35 | 13 | 10 | 12 | 37:42 | -5 | 49 |
| 11 |
|
Tottenham Hotspur | 35 | 12 | 9 | 14 | 42:49 | -7 | 45 |
| 12 |
|
Newcastle United | 35 | 12 | 9 | 14 | 40:47 | -7 | 45 |
| 13 |
|
Leicester City | 35 | 13 | 6 | 16 | 34:45 | -11 | 45 |
| 14 |
|
West Ham United | 35 | 9 | 12 | 14 | 41:47 | -6 | 39 |
| 15 |
|
Middlesbrough FC | 35 | 8 | 14 | 13 | 41:40 | 1 | 38 |
| 16 |
|
Everton FC | 35 | 10 | 8 | 17 | 40:54 | -14 | 38 |
| 17 |
|
Derby County | 35 | 9 | 11 | 15 | 34:56 | -22 | 38 |
| 18 |
|
Coventry City | 35 | 8 | 9 | 18 | 34:58 | -24 | 33 |
| 19 |
|
Manchester City | 35 | 7 | 10 | 18 | 38:61 | -23 | 31 |
| 20 |
|
Bradford City | 35 | 5 | 9 | 21 | 28:67 | -39 | 24 |