| 09/04/2022 | 15:00 | Spartak Subotica | - | FK Kolubara | 4:3 (0:1) | |
| 17:30 | Mladost Lučani | - | Radnički Niš | 2:0 (1:0) | ||
| 10/04/2022 | 13:00 | TSC Bačka Topola | - | FK Voždovac | 2:1 (2:1) | |
| 16:00 | Crvena Zvezda | - | FK Radnički 1923 | 4:1 (1:0) | ||
| 18:05 | FK Čukarički | - | Partizan | 0:0 (0:0) | ||
| 11/04/2022 | 17:30 | FK Napredak | - | FK Metalac | 1:0 (0:0) | |
| 17:30 | Vojvodina | - | Proleter Novi Sad | 2:1 (2:0) | ||
| 17:30 | Radnik Surdulica | - | FK Novi Pazar | 2:0 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Crvena Zvezda | 30 | 26 | 3 | 1 | 79:17 | 62 | 81 |
| 2 |
|
Partizan | 30 | 25 | 4 | 1 | 68:10 | 58 | 79 |
| 3 |
|
FK Čukarički | 30 | 14 | 12 | 4 | 48:27 | 21 | 54 |
| 4 |
|
TSC Bačka Topola | 30 | 11 | 8 | 11 | 44:41 | 3 | 41 |
| 5 |
|
FK Voždovac | 30 | 11 | 7 | 12 | 41:37 | 4 | 40 |
| 6 |
|
Radnički Niš | 30 | 9 | 13 | 8 | 32:33 | -1 | 40 |
| 7 |
|
Vojvodina | 30 | 11 | 6 | 13 | 38:40 | -2 | 39 |
| 8 |
|
FK Napredak | 30 | 10 | 7 | 13 | 31:36 | -5 | 37 |
| 9 |
|
Mladost Lučani | 30 | 10 | 6 | 14 | 38:44 | -6 | 36 |
| 10 |
|
Radnik Surdulica | 30 | 8 | 12 | 10 | 24:31 | -7 | 36 |
| 11 |
|
Spartak Subotica | 30 | 9 | 7 | 14 | 35:49 | -14 | 34 |
| 12 |
|
FK Kolubara | 30 | 10 | 4 | 16 | 32:56 | -24 | 34 |
| 13 |
|
FK Radnički 1923 | 30 | 8 | 6 | 16 | 27:50 | -23 | 30 |
| 14 |
|
Proleter Novi Sad | 30 | 8 | 5 | 17 | 23:49 | -26 | 29 |
| 15 |
|
FK Metalac | 30 | 7 | 6 | 17 | 36:52 | -16 | 27 |
| 16 |
|
FK Novi Pazar | 30 | 5 | 10 | 15 | 25:49 | -24 | 25 |
| Playoffs | |
| Playoffs |