| 13/05/2022 | 16:30 | 1. FSV Mainz 05 II | - | TSG Balingen | 3:2 (2:1) | |
| 14/05/2022 | 13:00 | FC-Astoria Walldorf | - | VfR Aalen | 0:2 (0:2) | |
| 13:00 | Hessen Kassel | - | FC Gießen | 3:0 (1:0) | ||
| 13:00 | Kickers Offenbach | - | FSV Frankfurt | 4:0 (2:0) | ||
| 13:00 | Rot-Weiß Koblenz | - | SG Sonnenhof Großaspach | 0:1 (0:0) | ||
| 13:00 | SSV Ulm 1846 | - | VfB Stuttgart II | 3:2 (1:1) | ||
| 13:00 | SV 07 Elversberg | - | FC 08 Homburg | 2:0 (1:0) | ||
| 13:00 | 1899 Hoffenheim II | - | TSV Steinbach Haiger | 0:2 (0:2) | ||
| 13:00 | TSV Schott Mainz | - | Bahlinger SC | 3:0 (1:0) |
| » Tables | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV 07 Elversberg | 36 | 24 | 8 | 4 | 79:29 | 50 | 80 |
| 2 |
|
SSV Ulm 1846 | 36 | 23 | 8 | 5 | 60:30 | 30 | 77 |
| 3 |
|
Kickers Offenbach | 36 | 24 | 4 | 8 | 67:26 | 41 | 76 |
| 4 |
|
TSV Steinbach Haiger | 36 | 20 | 10 | 6 | 62:35 | 27 | 70 |
| 5 |
|
1. FSV Mainz 05 II | 36 | 22 | 3 | 11 | 63:42 | 21 | 69 |
| 6 |
|
FC 08 Homburg | 36 | 14 | 10 | 12 | 43:48 | -5 | 52 |
| 7 |
|
Hessen Kassel | 36 | 13 | 12 | 11 | 46:37 | 9 | 51 |
| 8 |
|
TSG Balingen | 36 | 13 | 7 | 16 | 46:64 | -18 | 46 |
| 9 |
|
Bahlinger SC | 36 | 12 | 9 | 15 | 35:44 | -9 | 45 |
| 10 |
|
FC-Astoria Walldorf | 36 | 12 | 8 | 16 | 49:61 | -12 | 44 |
| 11 |
|
VfB Stuttgart II | 36 | 12 | 7 | 17 | 49:52 | -3 | 43 |
| 12 |
|
VfR Aalen | 36 | 12 | 7 | 17 | 49:60 | -11 | 43 |
| 13 |
|
1899 Hoffenheim II | 36 | 10 | 11 | 15 | 45:50 | -5 | 41 |
| 14 |
|
Rot-Weiß Koblenz | 36 | 9 | 12 | 15 | 36:44 | -8 | 39 |
| 15 |
|
FSV Frankfurt | 36 | 9 | 12 | 15 | 40:53 | -13 | 39 |
| 16 |
|
SG Sonnenhof Großaspach | 36 | 11 | 6 | 19 | 42:64 | -22 | 39 |
| 17 |
|
TSV Schott Mainz | 36 | 9 | 6 | 21 | 36:58 | -22 | 33 |
| 18 |
|
FK Pirmasens | 36 | 9 | 6 | 21 | 32:59 | -27 | 33 |
| 19 |
|
FC Gießen | 36 | 7 | 8 | 21 | 28:51 | -23 | 29 |
| Promotion | |
| Relegation |