| 04/03/2016 | 23:00 | Guaraní | - | Club Olimpia | 0:2 (0:1) | |
| 05/03/2016 | 22:00 | River Plate | - | Club Rubio Ñu | 1:4 (1:2) | |
| 23:00 | Cerro Porteño | - | Club Nacional | 1:2 (0:0) | ||
| 06/03/2016 | 21:00 | General Díaz | - | Deportivo Capiatá | 2:2 (1:0) | |
| 21:00 | General Caballero ZC | - | Sol de América | 1:1 (0:1) | ||
| 23:10 | Sportivo Luqueño | - | Libertad | 0:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sol de América | 9 | 5 | 3 | 1 | 20:13 | 7 | 18 |
| 2 |
|
Club Rubio Ñu | 9 | 5 | 3 | 1 | 15:9 | 6 | 18 |
| 3 |
|
Libertad | 9 | 5 | 0 | 4 | 14:10 | 4 | 15 |
| 4 |
|
Sportivo Luqueño | 9 | 4 | 3 | 2 | 13:11 | 2 | 15 |
| 5 |
|
General Díaz | 9 | 4 | 3 | 2 | 17:16 | 1 | 15 |
| 6 |
|
Deportivo Capiatá | 9 | 3 | 4 | 2 | 19:17 | 2 | 13 |
| 7 |
|
Club Nacional | 9 | 3 | 2 | 4 | 16:18 | -2 | 11 |
| 8 |
|
Club Olimpia | 9 | 3 | 1 | 5 | 16:15 | 1 | 10 |
| 9 |
|
Cerro Porteño | 9 | 3 | 1 | 5 | 11:12 | -1 | 10 |
| 10 |
|
General Caballero ZC | 9 | 2 | 3 | 4 | 11:17 | -6 | 9 |
| 11 |
|
River Plate | 9 | 1 | 4 | 4 | 5:12 | -7 | 7 |
| 12 |
|
Guaraní | 9 | 1 | 3 | 5 | 9:16 | -7 | 6 |
| Copa Libertadores |